查看“︁高丝氨酸脱氢酶”︁的源代码

{{noteTA
|G1=生命科学
|G2=Chemistry
}}
{{enzyme
| Name = 高丝氨酸脱氢酶
| Systematic_name = L-homoserine:NAD(P)<sup>+</sup> oxidoreductase
| Acronym = HSDH; HSD
| Other_names = 
| EC_number = 1.1.1.3
| CAS_number = 9028-13-1 | IUBMB_EC_number = 1/1/1/3 | GO_code = 0004412 | image = PDB 1ebu EBI.jpg
| width = 
| caption = 结合了NAD类似物和L-高丝氨酸的高丝氨酸脱氢酶复合物
}}
'''高丝氨酸脱氢酶'''（{{lang-en|homoserine dehydrogenase}}，[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.3 1.1.1.3] {{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.3 |date=20201126230941 }}）是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]：

:[[L-高丝氨酸]] + [[烟酰胺腺嘌呤二核苷酸|NAD]]([[烟酰胺腺嘌呤二核苷酸磷酸|P]]) <math>\rightleftharpoons</math> [[L-天冬氨酸半醛]] + NAD(P)H + [[氢离子|H<sup>+</sup>]]

高丝氨酸脱氢酶参与[[甘氨酸]]、[[丝氨酸]]和[[苏氨酸]]的[[代谢]]以及[[赖氨酸]]的[[生物合成]]。高丝氨酸脱氢酶参与[[天冬氨酸途径]]的第三步反应，在NAD或NADP的参与下将[[天冬氨酸半醛]]还原为[[高丝氨酸]]。<ref name="pmid8500624">{{cite journal | author = Thomas D, Barbey R, Surdin-Kerjan Y | title = Evolutionary relationships between yeast and bacterial homoserine dehydrogenases | journal = FEBS Lett. | volume = 323 | issue = 3 | pages = 289–93 | pmid = 8500624 | doi = 10.1016/0014-5793(93)81359-8| url = |date=June 1993}}</ref><ref name="pmid8395899">{{cite journal | author = Cami B, Clepet C, Patte JC | title = Evolutionary comparisons of three enzymes of the threonine biosynthetic pathway among several microbial species | journal = Biochimie | volume = 75 | issue = 6 | pages = 487–95 | year = 1993 | pmid = 8395899 | doi = | url =https://archive.org/details/sim_biochimie_1993_75_6/page/487}}</ref>

== 参考文献 ==
{{refbegin}}
{{reflist}}
* {{cite journal | author = BLACK S, WRIGHT NG | year = 1955 | title = Homoserine dehydrogenase | journal = J. Biol. Chem.  | volume = 213 | pages = 51–60  | pmid = 14353905 | issue = 1 }}{{Wordbreak}}* {{cite journal | author = Starnes WL, Munk P, Maul SB, Cunningham GN, Cox DJ, Shive W | year = 1972 | title = Threonine-sensitive aspartokinase-homoserine dehydrogenase complex, amino acid composition, molecular weight, and subunit composition of the complex | journal = Biochemistry.  | volume = 11 | pages = 677–87  | pmid = 4551091 | doi = 10.1021/bi00755a003 | issue = 5 }}
* {{cite journal | author = Veron M, Falcoz-Kelly F, Cohen GN | year = 1972 | title = The threonine-sensitive homoserine dehydrogenase and aspartokinase activities of Escherichia coli K12. The two catalytic activities are carried by two independent regions of the polypeptide chain | journal = Eur. J. Biochem.  | volume = 28 | pages = 520–7  | pmid = 4562990 | doi = 10.1111/j.1432-1033.1972.tb01939.x | issue = 4 }}
{{refend}}

{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NAD依赖性酶]]
[[Category:NADH依赖性酶]]
[[Category:NADPH依赖性酶]]
[[Category:已知结构的酶]]