查看“︁苹果酸合酶”︁的源代码

{{enzyme
| Name = 苹果酸合酶<br>malate synthase
| EC_number = 2.3.3.9
| CAS_number = 9013-48-3
| IUBMB_EC_number = 2/3/3/9
| GO_code = 0004474
| image = 
| width = 
| caption = 
}}
'''苹果酸合酶'''（{{lang-en|malate synthase}}，{{EC number|2.3.3.9}}）是能[[催化]]如下[[反应]]的[[酶]]:

:[[乙酰辅酶A|乙酰-CoA]] + H<sub>2</sub>O + [[乙醛酸]] <math>\rightleftharpoons</math> [[苹果酸|(S)-苹果酸]] + [[辅酶A|CoA]]

该酶属于[[轉移酶]]中{{le|酰基转移酶|acyltransferases}}的一类，并在转移过程中把[[酰基]]转化为[[烷基]]。苹果酸合酶参与了[[乙醛酸循环]]。

==结构研究==

截止2018年底，已有几个这类酶的[[蛋白質三級結構|结构]]被解析，包括[[蛋白質資料庫|PDB]]接入代码为[https://www.rcsb.org/structure/2GQ3 2GQ3] {{Wayback|url=https://www.rcsb.org/structure/2GQ3 |date=20220705232800 }}, [https://www.rcsb.org/structure/1D8C 1D8C] {{Wayback|url=https://www.rcsb.org/structure/1D8C |date=20211201091054 }}, [https://www.rcsb.org/structure/3OYX 3OYX] {{Wayback|url=https://www.rcsb.org/structure/3OYX |date=20220705192319 }}, [https://www.rcsb.org/structure/3PUG 3PUG] {{Wayback|url=https://www.rcsb.org/structure/3PUG |date=20220705192321 }}, [https://www.rcsb.org/structure/5TAO 5TAO] {{Wayback|url=https://www.rcsb.org/structure/5TAO |date=20220705224231 }}, [https://www.rcsb.org/structure/5H8M 5H8M] {{Wayback|url=https://www.rcsb.org/structure/5H8M |date=20220705192320 }}, [https://www.rcsb.org/structure/2JQX 2JQX] {{Wayback|url=https://www.rcsb.org/structure/2JQX |date=20220705232501 }}, [https://www.rcsb.org/structure/1P7T 1P7T] {{Wayback|url=https://www.rcsb.org/structure/1P7T |date=20220705232447 }}, 和 [https://www.rcsb.org/structure/1Y8B 1Y8B] {{Wayback|url=https://www.rcsb.org/structure/1Y8B |date=20220705224235 }}.<ref>{{Cite web|url=https://www.rcsb.org/|title=RCSB PDB: Homepage|last=Bank|first=RCSB Protein Data|website=www.rcsb.org|language=en|access-date=2018-03-05|archive-date=2022-12-07|archive-url=https://web.archive.org/web/20221207212420/https://www1.rcsb.org/|dead-url=no}}</ref>。

==参考文献==
{{reflist|1}}
* {{cite journal | author = DIXON GH, KORNBERG HL, LUND P | date = 1960 | title = Purification and properties of malate synthetase | journal = Biochim. Biophys. Acta.  | volume = 41 | issue = 2 | pages = 217–33  | pmid = 13816984 | doi = 10.1016/0006-3002(60)90004-4 }}

{{酰基转移酶类}}

[[Category:EC 2.3.3]]
[[Category:已知结构的酶]]