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{{multiple issues| {{inappropriate tone|time=2014-06-10T08:21:35+00:00}} {{newsrelease|time=2014-06-10T08:21:35+00:00}} {{orphan|time=2016-04-24T18:21:05+00:00}} }} {{Infobox scientist | birth_date = {{birth date and age|1938|9|9|df=yes}} | birth_place = {{TWN-JPN}}[[新竹州]] | nationality = {{ROC}} | field = [[理論生物學]]、[[藥理學]]、{{le|癌症研究|Cancer Research}}<ref>[http://www.researcherid.com/rid/B-4111-2009, by Thomson Reuters Web of Science for "Ting-Chao_Chou"]{{Dead link|date=2019年11月 |bot=InternetArchiveBot |fix-attempted=yes }}</ref> | work_institution = [[耶魯大學]]<br>[[约翰霍普金斯大学]]<br>[[康奈爾大學]] [[斯隆凯特琳癌症中心]] (2013年6月1日退休) | known_for = * Median-effect Equation, the Unified Theory of the Mass-Action Law * Combination Index {CI} defines Synergism (CI<1), Additive Effect (CI=1) and Antagonism (CI>1) with computerized simulations using Compusyn or CalcuSyn * Dose Reduction Index (DRI), Normalized Isobologram, and Polygonogram * Econo-Green Bio-research and Development * Quantitative Bio-Informatics * Fludelone, Iso-oxazole-Fludelone, Panaxytriols, Ardeemins * Illustration of Ancient Chinese Philosophy with Modern Sciences }} '''周廷潮'''({{lang-en|Ting-Chao Chou}},{{bd|1938年|9月9日}})美籍华裔[[理论生物学]]家,[[癌症]]药物学家。[[耶鲁大学]]<ref name="耶鲁大学">{{Cite web |url=http://pkunews.pku.edu.cn/zdlm/2008-10/21/content_130609.htm |title=耶鲁大学博士周廷潮教授北大谈古论今 |access-date=2014-03-28 |archive-url=https://web.archive.org/web/20140328121606/http://pkunews.pku.edu.cn/zdlm/2008-10/21/content_130609.htm |archive-date=2014-03-28 |dead-url=yes }}</ref>博士,曾任[[康奈尔大学]]教授及[[纽约]]{{link-en|斯隆凯特琳癌症中心|Memorial Sloan-Kettering Cancer Center}}<ref name="ncic">{{Cite web |url=http://prof.ncic.ac.cn/person/190364 |title=周廷潮,国家智能计算机研究开发中心 |accessdate=2014-03-28 |archive-date=2014-03-28 |archive-url=https://web.archive.org/web/20140328114347/http://prof.ncic.ac.cn/person/190364 |dead-url=yes }}</ref>临床前药理主任,也是[[中国医学科学院]]名誉教授。發表數百篇論文,[[H指數]]為67<REF> {{Cite web |url=https://scholar.google.de/citations?user=xjcodA8AAAAJ&hl=en |title=Google Scholar Ting-Chao Chou |accessdate=2016-05-04 |archive-date=2019-08-03 |archive-url=https://web.archive.org/web/20190803010214/https://scholar.google.de/citations?user=xjcodA8AAAAJ&hl=en |dead-url=no }} </ref>。 ==生平及事迹== 周廷潮1938年9月9日出生於[[台灣日治时期]]的[[新竹郡]][[湖口庄]]長岡嶺。[[新竹中学]]及[[高雄医学院]]药学系毕业,[[台湾大学]]医学院硕士,[[耶鲁大学]]博士。在[[约翰霍普金斯大学]]医学院师從药理主任{{le|保羅·塔拉雷|Paul Talalay}}教授/院士從事博士后研究。于1972年受聘于斯隆凯特琳癌症中心及康乃尔大学医学研究院担任教职,于1988年升任教授。 周廷潮曾任[[中国医学科学院]]名誉教授,[[南京医科大学]]、[[同济医科大学]]客座教授。 周氏「质量作用中效定理」<ref name="The median-effect equation">{{Cite web |url=http://www.sciencedirect.com/science/article/pii/0022519376901697 |title=Derivation and properties of Michaelis-Menten type and Hill type equations for reference ligands |accessdate=2016-05-04 |archive-date=2018-12-11 |archive-url=https://web.archive.org/web/20181211015829/https://www.sciencedirect.com/science/article/pii/0022519376901697 |dead-url=no }}</ref>,于1976年提出,已发展成普世通用定理(The Median-Effect Equation As the Unified Theory)。周塔氏「药物合并指数定理」(The Combination Index Theorem)于1984年提出<ref name="Chou_Talalay"/>。周氏与科研伙伴擁有39个美国专利。与丹尼雪夫斯基教授发明了依波西隆抗癌化合物,以及從高丽参主成分改造研发的细胞保护剂,大量减低化疗及放射疗法所产生的毒性。 周氏理论另有二项主要进展,一是应用于高效益绿色医药研发<ref name="医药研发">{{Cite web |url=http://www.biosino.org/news-2001/200107/01070604.htm |title=华裔专家研发抗癌新药 对八种癌症极为有效 |accessdate=2014-03-28 |archive-date=2014-03-29 |archive-url=https://web.archive.org/web/20140329215729/http://www.biosino.org/news-2001/200107/01070604.htm |dead-url=yes }}</ref>(Econo-Green Bio-Research and Development)及电脑自动化演析。另一是提出中国古代哲学的现代数理新义诠释,已发表于四个国际哲学会議(包括2007年的美国哲学会东区年会及2008年的世界哲学大会<ref>{{Cite web |url=http://www.pdcnet.org/wcp22/content/wcp22_2008_0002_0021_0039 |title=A New Look at the Ancient Asian Philosophy through Modern Mathematical and Topological Scientific Analysis World Congress of Philosophy, 2008, Seoul |accessdate=2014-03-27 |archive-date=2019-10-30 |archive-url=https://web.archive.org/web/20191030152618/https://www.pdcnet.org/wcp22/content/wcp22_2008_0002_0021_0039 |dead-url=no }}</ref>),也曾在北京大學等地發表演講<ref>{{Cite web |url=http://pkunews.pku.edu.cn/zdlm/2008-10/21/content_130609.htm |title=Peking University Speech, 10/24/2008 |access-date=2014-03-28 |archive-url=https://web.archive.org/web/20140328121606/http://pkunews.pku.edu.cn/zdlm/2008-10/21/content_130609.htm |archive-date=2014-03-28 |dead-url=yes }}</ref>。 ==科学研究及创作== 周廷潮发表數百篇著作,其中理论及实验约各半。收录入{{le|Web of Science|Web Of Science}} 及[[Google学术搜索]]。包括原著、评论、前瞻、美国专利、学术会议论文摘要及电脑软件等。 ===质量作用中效定理=== 质量作用中效定理(Median-Effect Principle)是周廷潮1976年正式提出的定理<ref name="The median-effect equation"/>,以物理及化学质量作用原理为模型及[[酵素动力学]]做系统分析,再以数学演绎归纳为方案下所提出的: <math>\frac{fa}{fu} = \left ( \frac{D}{Dm} \right )^m</math> 其中致效(Fa)与不致效(Fu)之比例等于[[剂量]](D)与中效剂量(Dm)之比例的m次方。Dm为剂量作用之中效强度指标;m=1为[[抛物线]],m>1为S型双曲线,而m<1为扁双曲线。 符合物理、化学质量作用原理的任何剂效图形,可以用周氏剂效图解(The Median-Effect Plot)转换成直线。其斜度即为m值,而X轴交切点即为<math>log(Dm)</math> 值。在取得剂效资料后,可以用电脑软件CompuSyn<ref>{{Cite web |url=http://www.combosyn.com/ |title=CompuSyn Software by Chou & Martin, 2005, Combosyn, Inc., Paramus, NJ. Free download. 2012- |accessdate=2016-05-01 |archive-date=2020-12-01 |archive-url=https://web.archive.org/web/20201201044957/http://www.combosyn.com/ |dead-url=no }}</ref>或CalcuSyn<ref>{{Cite web |url=http://www.biosoft.com/w/calcusyn.htm |title=CalcuSyn Software by Chou & Hayball, 1998, Biosoft, Cambridge, UK |accessdate=2014-03-27 |archive-date=2020-06-16 |archive-url=https://web.archive.org/web/20200616164133/http://biosoft.com/w/calcusyn.htm |dead-url=no }}</ref> 演算m及Dm值,并且显示出剂效电脑拟模图形。 周氏进一步证明;中效质量(Dm)是普世联接点及指标点,不管是单一物质(n=1)或是复方物质(n>1);不管是一级动力学层次(m=1)或是高等动力学层次(m≠1)皆能通用。此为剂效关系最精简的表达,也是[[酵素动力学]]的[[米氏動力學]],[[阿奇博爾德·希爾]]的高动力学层次常数公式,有關氫離子解離的[[亨德森-哈塞爾巴爾赫方程]],以及Scatchard的受体分离常数公式的共同表述{{fact}}。 ===药物合并指数定理=== 药物合并指数定理(The Combination Index Theorem)及电脑解析是1984年由周廷潮及塔氏(Talalay)提出的定理,是从单一物质到复方物质的系统推广<ref name="Chou_Talalay">{{cite journal | url=http://www.sciencedirect.com/science/article/pii/0065257184900074 | title=Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors | author=Ting-Chao Chou, Paul Talalay | journal=Advances in Enzyme Regulation | year=1984 | volume=22 | pages=27-55 | doi=10.1016/0065-2571(84)90007-4 | access-date=2016-05-04 | archive-date=2018-12-11 | archive-url=https://web.archive.org/web/20181211100411/https://www.sciencedirect.com/science/article/pii/0065257184900074 }}</ref>。合并指数(CI)可以定量[[协同作用]](CI<1),相加作用(CI=1),及[[拮抗作用]](CI>1)。其二药合并之公式为: :<math>CI=\frac{(D)_1}{(D_x)_1}+\frac{(D)_2}{(D_x)_2}=\frac{(D)_1}{(D_m)_1[f_a/(1-f_a)]^{1/m_1} }+\frac{(D)_2}{(D_m)_2[f_a/(1-f_a)]^{1/m_2} }</math> 其中 :<math>(D_x)_1</math>是<math>(D)_1</math>单独时抑制x% 之剂量 :<math>(D_x)_2</math>是<math>(D)_2</math>单独时抑制x% 之剂量。 而在二项之分子上<math>(D)_1</math>+<math>(D)_2</math>合并时也抑制x% 之剂量,而fa、m、Dm之定义如上节所示。 使用CompuSyn电脑软件输入各单药及其合并在各剂量之效用(fa值),则fa-CI图形(Chou-Talalay Plot)自动扫描测定药物之协同或拮抗作用。此方法给予研究机构,药检局,制药厂及专利局制定药物合并事项提供严格定量标准。三个以上药物之合并理论已落实,亦可自动化解析。癌症治疗常用多种药物,治疗爱滋病多用[[鸡尾酒疗法]],中医多用复方,這些的现代化定量解析可以應用CI方法及其程式進行。 ===高效益绿色医药研发=== 高效益绿色医药研发是以上述定理為基礎的医药研发。剂效图形可以转换成直线的论述,导致观念上的基本突破。此即至少两点数据(精简资料),则可电脑拟模全程剂效曲线(Two Points Minimum for Dose-Effect Curve)。用此定理可由少数资料点,去配对“自然法则”(质量作用定理)。如此可以進行小型实验、少数据、少时间、少用动物、少用病人于临床实验的[[绿色医药研发]]<ref>{{Cite web |url=http://blogs.rsc.org/ib/2011/05/05/hot-one-equation-to-lead-the-way-to-greener-biomedical-sciences/ |title=HOT: one equation to lead the way to greener biomedical sciences |access-date=2014-03-27 |archive-url=https://web.archive.org/web/20160304023110/http://blogs.rsc.org/ib/2011/05/05/hot-one-equation-to-lead-the-way-to-greener-biomedical-sciences/ |archive-date=2016-03-04 |dead-url=yes }}</ref><ref>{{Cite web |url=http://jnci.oxfordjournals.org/content/86/20/1517 |title=Computerized Quantitation of Synergism and Antagonism of Taxol, Topotecan, and Cisplatin Against Human Teratocarcinoma Cell Growth: a Rational Approach to Clinical Protocol Design |access-date=2014-03-27 |archive-date=2016-03-26 |archive-url=https://web.archive.org/web/20160326150538/http://jnci.oxfordjournals.org/content/86/20/1517 }}</ref><ref>{{Cite web |url=http://cancerres.aacrjournals.org/content/70/2/440.full |title=Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method |accessdate=2014-03-27 |archive-date=2013-02-27 |archive-url=https://web.archive.org/web/20130227092124/http://cancerres.aacrjournals.org/content/70/2/440.full |dead-url=no }}</ref><ref>{{Cite web |url=http://www.bio-itworldexpoeurope.com/bio-it_europe_content.aspx?id=106874&libID=106831 |title=Drug Discovery Informatics |accessdate=2014-03-27 |archive-date=2011-11-21 |archive-url=https://web.archive.org/web/20111121022654/http://www.bio-itworldexpoeurope.com/Bio-It_Europe_Content.aspx?id=106874&libID=106831 |dead-url=no }}</ref><ref>{{Cite web |url=http://www.worldcat.org/title/dose-effect-analysis-with-microcomputers/oclc/20772177 |title=Dose-effect analysis with microcomputers |accessdate=2016-04-24 |archive-date=2019-10-19 |archive-url=https://web.archive.org/web/20191019090641/https://www.worldcat.org/title/dose-effect-analysis-with-microcomputers/oclc/20772177 |dead-url=no }}</ref> <ref>{{Cite web |url=http://dspace.mit.edu/handle/1721.1/90152 |title=Computational analysis of biochemical networks for drug target identification and therapeutic intervention design |accessdate=2016-04-24 |archive-date=2019-10-14 |archive-url=https://web.archive.org/web/20191014004259/https://dspace.mit.edu/handle/1721.1/90152 |dead-url=no }}</ref> ==专利发明== 周氏发明以抗细胞微管为标的的{{link-en|依波西隆|Epothilone}}[[抗癌]]化合物,以及以DNA[[烷化剂]]为标的抗癌药物。此外有抗排斥之器官移植免疫抑制剂,以及從高丽参主成分化学改造合成的高丽参精三醇化合物{{le|Panaxytriols|Panaxytriols}},用于细胞保护以及减少[[化学疗法]]及[[放射治疗]]所产生的毒性及副作用<ref>{{Cite web |url=http://patentscope.wipo.int/search/en/WO2008103916 |title=Panaxytriols Patent |accessdate=2014-03-27 |archive-date=2013-10-22 |archive-url=https://web.archive.org/web/20131022130219/http://patentscope.wipo.int/search/en/WO2008103916 |dead-url=no }}</ref><ref>{{Cite web |url=http://www.pnas.org/content/108/34/14336.full.pdf+html |title=Panaxytriols, PNAS Article, 2011 |accessdate=2014-03-27 |archive-date=2015-09-24 |archive-url=https://web.archive.org/web/20150924155332/http://www.pnas.org/content/108/34/14336.full.pdf+html |dead-url=no }}</ref><ref>{{Cite web |url=http://www.pnas.org/content/suppl/2011/08/09/1111332108.DCSupplemental/pnas.201111332SI.pdf |title=Panaxytriols, PNAS Supplements |access-date=2014-03-27 |archive-date=2019-10-20 |archive-url=https://web.archive.org/web/20191020094404/https://www.pnas.org/content/suppl/2011/08/09/1111332108.DCSupplemental/pnas.201111332SI.pdf }}</ref><ref>{{Cite web |url=http://cancerres.aacrjournals.org/content/65/20/9445 |title=Fludelone, Cancer Research Article 2005 |accessdate=2014-03-27 |archive-date=2017-09-10 |archive-url=https://web.archive.org/web/20170910211815/http://cancerres.aacrjournals.org/content/65/20/9445 |dead-url=no }}</ref><ref>{{Cite web |url=http://www.pnas.org/content/105/35/13157.full.pdf+html |title=Iso-oxazole-fludelone PNAS Article, 2008 |access-date=2014-03-27 |archive-date=2015-09-24 |archive-url=https://web.archive.org/web/20150924145918/http://www.pnas.org/content/105/35/13157.full.pdf+html }}</ref>,周廷潮與科研夥伴共同擁有美国专利共计39项<ref>{{Cite web |url=http://patent.ipexl.com/inventor/Ting-Chao_Chou_1.html |title=US Patents Full Listing |access-date=2014-03-27 |archive-url=https://web.archive.org/web/20160306103812/http://patent.ipexl.com/inventor/Ting-Chao_Chou_1.html |archive-date=2016-03-06 |dead-url=yes }}</ref><ref>{{Cite web |url=http://patents.justia.com/search?q=Ting-Chao+Chou&page=3 |title=US Patents Listing |access-date=2014-03-27 |archive-date=2019-11-09 |archive-url=https://web.archive.org/web/20191109134222/https://patents.justia.com/search?q=Ting-Chao+Chou&page=3 }}</ref><ref>{{Cite web |url=http://radaris.com/p/Ting-Chao/Chou/ |title=US Patents Partial Listing |accessdate=2014-03-27 |archive-date=2019-10-18 |archive-url=https://web.archive.org/web/20191018163332/https://radaris.com/p/Ting-Chao/Chou/ |dead-url=no }}</ref><ref>{{Cite web |url=http://www.faqs.org/patents/inventor/ting-chao-chou-paramus-us-1/ |title=US Patents Statistics |accessdate=2014-03-27 |archive-date=2016-03-04 |archive-url=https://web.archive.org/web/20160304073906/http://www.faqs.org/patents/inventor/ting-chao-chou-paramus-us-1/ |dead-url=no }}</ref>。 ==著作== 1. The Unified Theory * http://www.cell.com/trends/pharmacological-sciences/abstract/0165-6147(83)90490-X{{Wayback|url=http://www.cell.com/trends/pharmacological-sciences/abstract/0165-6147(83)90490-X |date=20131017065901 }} [A New Look at A Very Old Problem] (Cited 382 times) * http://cancerres.aacrjournals.org/content/70/2/440.full{{Wayback|url=http://cancerres.aacrjournals.org/content/70/2/440.full |date=20130227092124 }} [Perspective Article, 2010 ] (Cited 828 times in 237 journals) * http://www.sciencedirect.com/science/article/pii/0022519372900409{{Wayback|url=http://www.sciencedirect.com/science/article/pii/0022519372900409 |date=20181211004407 }} [Combinatory Analysis, J Theor Biol 1972] * http://www.jbc.org/content/252/18/6438.full.pdf{{Wayback|url=http://www.jbc.org/content/252/18/6438.full.pdf |date=20200125142737 }} [Theoretical Development] (Cited 201 times) (Chou - Talalay Theory, 1977). * http://www.zoominfo.com/p/Ting-Chao-Chou/1326248255 [FEBS article 1981] * http://onlinelibrary.wiley.com/doi/10.1111/j.1432-1033.1981.tb06218.x/full{{Wayback|url=http://onlinelibrary.wiley.com/doi/10.1111/j.1432-1033.1981.tb06218.x/full |date=20170319055921 }} [Basic Theory, 1981 FEBS] * https://archive.today/20160424021210/http://libra.msra.cn/Publication/35878781/analysis-of-combined-drug-effects-a-new-look-at-a-very-old-problem [TIPS Trend Article, 1983] * http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196289/ [AJCR review article, 2011] * http://www.tandfonline.com/doi/abs/10.1080/10428190802353591?journalCode=ilal20 [Leukemia & Lymphoma clinical review article, 2008] * https://web.archive.org/web/20141226071743/http://omicsonline.org/1948-5964/1948-5964.S1.1-5.pdf [Virology-2011 Published in Antivir Antiretrovir, vol 3 issue 4-6] (Keynote Speech) * http://www.nature.com/nm/journal/v6/n2/full/nm0200_200.html {{Wayback|url=http://www.nature.com/nm/journal/v6/n2/full/nm0200_200.html |date=20051204065734 }} [Nature Medicine 6:200-206, 2000] [Cited 844 times as of 1/19/2016] * http://www.amazon.com/books/dp/0121740900 [Book, Academic Press, 1991] * http://www.sciencedirect.com/science/article/pii/S2213713014000042 {{Wayback|url=http://www.sciencedirect.com/science/article/pii/S2213713014000042 |date=20181211061040 }} [Synergy journal inaugural article by Chou, 2014] * https://web.archive.org/web/20160306094848/http://regulatoryaffairs.pharmaceuticalconferences.com/speaker/2015/ting-chao-chou-pd-science-llc-usa [Pharmaceutical Regulatory Affairs -Keynote Speech, Orlando, FL Aug..3 2015] * http://scholar.google.com/scholar?start=0&q=%22author:Chou+author:Ting-Chao.%22&hl=en&as_sdt=0,31 [Chou TC, 341 Publications & Their Citations] ==參考資料== {{reflist}} == 外部链接 == * https://hub.jhu.edu/2019/04/10/society-of-scholars-induction-ceremony/ {{Wayback|url=https://hub.jhu.edu/2019/04/10/society-of-scholars-induction-ceremony/ |date=20221016074620 }} * https://gsas.yale.edu/news/ting-chao-chou-70-phd-inducted-society-scholars-johns-hopkins {{Wayback|url=https://gsas.yale.edu/news/ting-chao-chou-70-phd-inducted-society-scholars-johns-hopkins |date=20221016074620 }} * T.C. Chou, The Mass-Action Law for Bio-Informatics. Nature Precedings, 7/22/2008 {{Wayback|url=http://precedings.nature.com/documents/2064/version/2 |date=20200122183941 }} * Comments on Chou's Speech in Beijing by Muyu in Sohu Blog, in Chinese{{Wayback|url=http://laoyouji000.blog.sohu.com/102704065.html |date=20181008014946 }} * [http://libgallery.cshl.edu/items/show/32731 Chou's letter to Prof. James D. Watson. 10/6/1974, Cold Spring Harbor Laboratory Archives Repository] {{Wayback|url=http://libgallery.cshl.edu/items/show/32731 |date=20181003232447 }} * [http://tingchaochou.blogspot.com/ 周廷潮的部落格]{{Wayback|url=http://tingchaochou.blogspot.com/ |date=20190804174123 }} * [https://web.archive.org/web/20160810040132/http://www.worldjournal.com/3369299/ 《人物》科學家周廷潮 理論引用世界第一 | 世界新聞網 ] * https://www.mskcc.org/blog/finding-treatments-nature {{Wayback|url=https://www.mskcc.org/blog/finding-treatments-nature |date=20160313102304 }} [MSKCC News] * http://blogs.rsc.org/ib/2011/05/05/hot-one-equation-to-lead-the-way-to-greener-biomedical-sciences/ {{Wayback|url=http://blogs.rsc.org/ib/2011/05/05/hot-one-equation-to-lead-the-way-to-greener-biomedical-sciences/ |date=20160304023110 }} [Integrative Biology Blogs, Royal Society of Chemistry, Cambridge, UK] * http://www.bio-itworldexpo.com/Bio-It_Europe_Content.aspx?id=106874&libID=106831 [Featured Speech BioIT World 2012. Hanover, Germany, on Drug Discovery Informatics] * http://regulatoryaffairs.pharmaceuticalconferences.com/speaker/2015/ting-chao-chou-pd-science-llc-usa {{Wayback|url=http://regulatoryaffairs.pharmaceuticalconferences.com/speaker/2015/ting-chao-chou-pd-science-llc-usa |date=20160306094848 }} [ Chou Opening Keynote Speech] * [[周廷潮]] [Chou TC Chinese Wikipedia 2017] * http://sp.mc.ntu.edu.tw/sopPage.php?malangue=&myrub=news&flanum=72884116445NWstLUUDpXSM6 {{Wayback|url=http://sp.mc.ntu.edu.tw/sopPage.php?malangue=&myrub=news&flanum=72884116445NWstLUUDpXSM6 |date=20221105213918 }} [Natl. Taiwan Univ-P Seminar Announcement 11/14/2016] * http://www.nibs.ac.cn/newsshow.php?cid=0&sid=14&id=408 {{Wayback|url=http://www.nibs.ac.cn/newsshow.php?cid=0&sid=14&id=408 |date=20221105213911 }} [China Natl. Inst. Biol. Sci., Beijing Seminar announcement 10/23/2008] * http://www.pdcnet.org/wcp22/content/wcp22_2008_0002_0021_0039 {{Wayback|url=http://www.pdcnet.org/wcp22/content/wcp22_2008_0002_0021_0039 |date=20191030152618 }} [World Congress of Philosophy, 2008, Seoul] * http://philpapers.org/rec/CHOANL {{Wayback|url=http://philpapers.org/rec/CHOANL |date=20221105214955 }} [Philpapers online blogs] * http://www.yijing.co.uk/conferences/2010-china/talks.html {{Wayback|url=http://www.yijing.co.uk/conferences/2010-china/talks.html |date=20221105214954 }} [Yijing World Conference- 2010. Wuxi, China. Press Release]. (Honorary Guest/Speaker) * http://www.gbv.de/dms/bs/toc/016060059.pdf {{Wayback|url=http://www.gbv.de/dms/bs/toc/016060059.pdf |date=20221207025648 }} [Book, Academic Press, 1991, Chou & Rideout, editors] * http://www.worldcat.org/title/dose-effect-analysis-with-microcomputers/oclc/20772177 {{Wayback|url=http://www.worldcat.org/title/dose-effect-analysis-with-microcomputers/oclc/20772177 |date=20191019090641 }} [Software by J.Chou & TC Chou, Biosoft, Cambridge, UK, 1985] * http://www.biosoft.com/w/calcusyn.htm {{Wayback|url=http://www.biosoft.com/w/calcusyn.htm |date=20200616164133 }} [CalcuSyn Software by Chou & Hayball, 1998, Biosoft, Cambridge, UK] * http://www.combosyn.com/ {{Wayback|url=http://www.combosyn.com/ |date=20201201044957 }} [CompuSyn Software by Chou & Martin, 2005, Combosyn, Inc., Paramus, NJ. Free download. 2012] * http://patents.justia.com/search?q=Ting-Chao+Chou&page=3 {{Wayback|url=http://patents.justia.com/search?q=Ting-Chao+Chou&page=3 |date=20191109134222 }} [Listing] * http://radaris.com/p/Ting-Chao/Chou/ {{Wayback|url=http://radaris.com/p/Ting-Chao/Chou/ |date=20191018163332 }} [Partial Listing] * https://archive.today/20130923161420/http://www.patentstorm.us/patents/8513429/description.html [US Patent on Epothilones, Issued 8/20/2013] * https://synapse.mskcc.org/synapse/people/7144-TingChao_Chou {{Wayback|url=https://synapse.mskcc.org/synapse/people/7144-TingChao_Chou |date=20221105215058 }} [MSKCC Chou Web Site] {{DEFAULTSORT:Chou, Ting-Chao}} [[Category:台灣生物學家]] [[Category:约翰斯·霍普金斯大学校友]] [[Category:耶魯大學校友]] [[Category:國立臺灣大學醫學院校友]] [[Category:高雄醫學院校友]] [[Category:國立新竹高級中學校友|周]] [[Category:湖口人]] [[Category:周姓]]
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