查看“︁吡哆醛4-脱氢酶”︁的源代码

{{enzyme
| Name = 吡哆醛4-脱氢酶
| Systematic_name = pyridoxal:NAD<sup>+</sup> oxidoreductase
| Acronym = PLDH
| Other_names = pyridoxal dehydrogenase
| EC_number = 1.1.1.107
| CAS_number = 37250-39-8
| IUBMB_EC_number = 1/1/1/107
| GO_code = 0050235
| image = 
| width = 
| caption = 
}}
'''吡哆醛4-脱氢酶'''（{{lang-en|pyridoxal 4-dehydrogenase}}，[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.107 1.1.1.107]{{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.107 |date=20200809152426 }}）也称为“'''吡哆醛脱氢酶'''”，是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]：

:[[吡哆醛]] + [[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]] <math>\rightleftharpoons</math> [[4-吡哆醇酮]] + NADH + [[氢离子|H<sup>+</sup>]]

吡哆醛4-脱氢酶[[分子]]由4个[[蛋白质亚基|亚基]]构成，每个亚基的[[相对分子质量]]为26,000±1,000[[原子质量单位|D]]。<ref>{{cite journal | author = Yokochi N, Nishimura S, Yoshikane Y, Ohnishi K, Yagi T. | title = Identification of a new tetrameric pyridoxal 4-dehydrogenase as the second enzyme in the degradation pathway for pyridoxine in a nitrogen-fixing symbiotic bacterium, ''Mesorhizobium loti''. | journal = Arch Biochem Biophys. | volume = 452 | pages = 1-8 | pmid = 16824480 | url = http://www.ncbi.nlm.nih.gov/pubmed/16824480 | date = 2006年1月1日 | access-date = 2012年8月17日 | archive-date = 2020年4月14日 | archive-url = https://web.archive.org/web/20200414150544/https://www.ncbi.nlm.nih.gov/pubmed/16824480 | dead-url = no }}</ref>这种酶主要参与[[维生素B6|维生素B<sub>6</sub>]]的[[代谢]]过程。<ref>{{cite journal | author = Nishimura S, Nagano S, A Crai C, Yokochi N, Yoshikane Y, Ge F, Yagi T. | title = Determination of individual vitamin B<sub>6</sub> compounds based on enzymatic conversion to 4-pyridoxolactone. | journal = J Nutr Sci Vitaminol (Tokyo). | volume = 54 | issue = 1 | pages = 18-24 | pmid = 18388403 | url = http://www.ncbi.nlm.nih.gov/pubmed/18388403 | date = Feb 2008 | access-date = 2012-08-17 | archive-date = 2020-04-14 | archive-url = https://web.archive.org/web/20200414150756/https://www.ncbi.nlm.nih.gov/pubmed/18388403 | dead-url = no }}</ref>已有学者提出可利用完整细胞生物转化技术（whole-cell biotransformation），以[[吡哆醇]]为[[原料]]、[[吡哆醇-4-氧化酶]]和吡哆醛4-脱氢酶为[[催化剂]]，来生产[[4-吡哆醇酮]]（4-pyridoxolactone，PAL）。<ref>{{cite journal | author = Tamura A, Yoshikane Y, Yokochi N, Yagi T. | title = Synthesis of 4-pyridoxolactone from pyridoxine using a combination of transformed ''Escherichia coli'' cells. | journal = J Biosci Bioeng. | volume = 106 | issue = 5 | pages = 460-465 | pmid = 19111641 | url = http://www.ncbi.nlm.nih.gov/pubmed/19111641 | date = Nov 2008 | access-date = 2012-08-17 | archive-date = 2020-04-14 | archive-url = https://web.archive.org/web/20200414150709/https://www.ncbi.nlm.nih.gov/pubmed/19111641 | dead-url = no }}</ref>

== 参考文献 ==
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{{refbegin}}
* {{cite journal | author = Burg RW, Snell EE | date = 1969 | title = The bacterial oxidation of vitamin B<sub>6</sub>. VI. Pyridoxal dehydrogenase and 4-pyridoxolactonase | journal = J. Biol. Chem.  | volume = 244 | pages = 2585-2589  | pmid = 4306030 | issue = 10 }}
{{refend}}

{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NADH依赖性酶]]
[[Category:未知结构的酶]]