查看“︁L-苏氨酸3-脱氢酶”︁的源代码

{{noteTA
|G1=生命科学
|G2=Chemistry
}}
{{enzyme
| Name = <small>L</small>-苏氨酸3-脱氢酶
| Systematic_name = <small>L</small>-threonine:NAD<sup>+</sup> oxidoreductase
| Acronym = THD
| Other_names = <small>L</small>-threonine dehydrogenase; threonine 3-dehydrogenase; threonine dehydrogenase
| EC_number = 1.1.1.103
| CAS_number = 9067-99-6
| IUBMB_EC_number = 1/1/1/103
| GO_code = 0008743
| image = 
| width = 
| caption = 
}}
'''<small>L</small>-苏氨酸3-脱氢酶'''（{{lang-en|<small>L</small>-threonine 3-dehydrogenase}}，[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.103 1.1.1.103] {{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.103 |date=20191114142759 }}），是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]：

:<small>L</small>-[[苏氨酸]] + [[烟酰胺腺嘌呤二核苷酸|NAD]]<sup>+</sup> <math>\rightleftharpoons</math> <small>L</small>-2-[[氨基]]-3-[[氧代丁酸]] + NADH + [[氢离子|H<sup>+</sup>]]

上述反应的[[产物]]<small>L</small>-2-氨基-3-氧代丁酸在[[水溶液]]中能自发转化为[[氨基丙酮]]。<small>L</small>-苏氨酸3-脱氢酶主要参与[[甘氨酸]]、[[丝氨酸]]和[[苏氨酸]]的[[代谢]]过程。这种酶能与[[甘氨酸C-乙酰基转移酶|甘氨酸''C''-乙酰基转移酶]]（glycine ''C''-acetyltransferase，[http://enzyme.expasy.org/EC/2.3.1.29 2.3.1.29] {{Wayback|url=http://enzyme.expasy.org/EC/2.3.1.29 |date=20201029224836 }}）结合成为[[复合物]]协同作用，参与苏氨酸的[[降解]]过程，该苏氨酸降解途径在[[原核细胞]]及[[真核细胞]]中都很常见。<ref>{{cite journal | author = Hartshorne D, Greenberg DM | date = 1964 | title =  Studies on liver threonine dehydrogenase |  journal = Arch. Biochem. Biophys.  | volume = 105 | pages = 173-178  | pmid = 14165492 | doi = 10.1016/0003-9861(64)90250-4 | url = http://www.sciencedirect.com/science/article/pii/0003986164902504 }}</ref>

== 参考文献 ==
{{reflist}}
{{refbegin}}
* {{cite journal | author = Green ML, Elliott WH | date = 1964 | title = The enzymic formation of aminoacetone from threonine and its further metabolism | journal = Biochem. J.  | volume = 92 | pages = 537-549  | pmid = 4284408 | issue = 3 | pmc = 1206098 | url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1206098/ }}
* {{cite journal | author = Newman, E.B., Kapoor, V. and Potter, R. | title = Role of <small>L</small>-threonine dehydrogenase in the catabolism of threonine and synthesis of glycine by ''Escherichia coli''. | journal =  J. Bacteriol. | volume = 126 | year = 1976 | pages = 1245- | pmid = 7548 | url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC233149/ }}
* {{cite journal | author = Epperly, B.R. and Dekker, E.E. | title = <small>L</small>-Threonine dehydrogenase from ''Escherichia coli''. Identification of an active site cysteine residue and metal ion studies. | journal = J. Biol. Chem. | volume = 266 | year = 1991 | pages = 6086-6092 | pmid = 2007567 | url = http://www.ncbi.nlm.nih.gov/pubmed/2007567 | access-date = 2012-08-08 | archive-date = 2016-03-04 | archive-url = https://web.archive.org/web/20160304023904/http://www.ncbi.nlm.nih.gov/pubmed/2007567 | dead-url = no }}
{{refend}}

{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NADH依赖性酶]]
[[Category:已知结构的酶]]