查看“︁L-乳酸脱氢酶”︁的源代码

{{DISPLAYTITLE:<small>L</small>-乳酸脱氢酶}}
{{enzyme
| Name = <small>L</small>-乳酸脱氢酶
| Systematic_name = (''S'')-lactate:NAD<sup>+</sup> oxidoreductase
| Acronym = 
| Other_names = lactic acid dehydrogenase; <small>L</small>(+)-nLDH; <small>L</small>-(+)-lactate dehydrogenase; <small>L</small>-lactic dehydrogenase; <small>L</small>-lactic acid dehydrogenase; lactate dehydrogenase; lactate dehydrogenase NAD-dependent; lactic dehydrogenase; NAD-lactate dehydrogenase
| EC_number = 1.1.1.27
| CAS_number = 9001-60-9 
| IUBMB_EC_number = 1/1/1/27 
| GO_code = 0004459 
| image = Lactate_dehydrogenase_M4_(muscle)_1I10.png
| width = 
| caption = 人源乳酸脱氢酶M<sub>4</sub>（在[[骨骼肌]]中发现的[[同工酶]]，[[蛋白质数据库|PDB]] 1I10）
}}
'''<small>L</small>-乳酸脱氢酶'''（{{lang-en|<small>L</small>-lactate dehydrogenase}}，[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.27 1.1.1.27] {{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.27 |date=20201127120116 }}）是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]：

:(''S'')-[[乳酸]] + [[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]] <math>\rightleftharpoons</math> [[丙酮酸]] + NADH + [[氢正离子|H<sup>+</sup>]]

在[[动物]][[细胞]]中NADP<sup>+</sup>也代替NAD<sup>+</sup>参与上述反应，只是[[反应速率]]较慢，而[[细菌]]则不能用NADP<sup>+</sup>替代NAD<sup>+</sup>。这种酶也能氧化其他(''S'')-2-[[羟基单羧酸]]。<small>L</small>-乳酸脱氢酶与<small>D</small>-乳酸脱氢酶统称“[[乳酸脱氢酶]]”。

== 参考文献 ==
{{refbegin}}
{{reflist}}
* {{cite journal | author = Dennis, D. and Kaplan, N.O. | title = D and L-lactic acid dehydrogenase in ''Lactobacillus plantarum''. | url = https://archive.org/details/sim_journal-of-biological-chemistry_1960-03_235_3/page/810 | journal = J. Biol. Chem. | volume = 235 | year = 1960 | pages = 810-818 | language = en}}
* {{cite journal | author = Everse, J. and Kaplan, N.O. | title = Lactate dehydrogenases: structure and function. | journal = Adv. Enzymol. Relat. Subj. Biochem. | volume = 37 | year = 1973 | pages = 61-133 | PMID = 4146647 | language = en}}
* {{cite book | author = Holbrook, J.J., Liljas, A., Steindel, S.J. and Rossmann, M.G. | chapter = Lactate dehydrogenase | title = The Enzymes | edition = 3rd | volume = 11 | publisher = Academic Press | location = New York | year = 1975 | pages = 191-292 | language = en}}
* {{cite journal | author = Schär, H.-P. and Zuber, H. | title = Structure and function of L-lactate dehydrogenases from thermophilic and mesophilic bacteria. I) Isolation and characterization of lactate dehydrogenases from thermophilic and mesophilic bacilli. | journal = Hoppe-Seyler's Z. Physiol. Chem. | volume = 360 | year = 1979 | pages = 795-807 | PMID = 114469 | language = en}}
{{refend}}

{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NADH依赖性酶]]
[[Category:已知结构的酶]]