查看“︁CYP51”︁的源代码

{{enzyme
| Name = sterol 14-demethylase
| EC_number = 1.14.13.70
| CAS_number = 
| IUBMB_EC_number = 1/14/13/70
| GO_code = 0008398
| image = 
| width = 
| caption = 
}}
'''细胞色素P450家族51'''，'''CYP51'''也称为'''甾醇-14-去甲基酶'''（{{lang-en|sterol 14-demethylase}}，{{EC number|1.14.13.70}}）是[[催化]]一系列14α-甲基甾醇去甲基化的[[酶]]。多种C29、C30[[甾醇]]底物可被CYP51家族的酶去甲基化<ref name="Lepesheva_2007">{{cite journal | vauthors = Lepesheva GI, Waterman MR | title = Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms | journal = Biochimica et Biophysica Acta | volume = 1770 | issue = 3 | pages = 467–77 | date = March 2007 | pmid = 16963187 | pmc = 2324071 | doi = 10.1016/j.bbagen.2006.07.018 }}</ref>，如[[ERG11|CYP51F1]]主要催化：

:[[钝叶醇]] + 3 O<sub>2</sub> + 3 [[NADPH]] + 3 H<sup>+</sup> <math>\rightleftharpoons</math> 4α-甲基-5α-麦角甾-8,14,24(28)-三烯-3β-ol + [[甲酸]] + 3 NADP<sup>+</sup> + 4 H<sub>2</sub>O

而[[CYP51A1]]在人体内催化[[2,3-环氧鲨烯]]环化为羊毛甾醇后的第一步反应：
:[[羊毛甾醇]] + 3 O<sub>2</sub> + 3 NADPH + 3 H<sup>+</sup> <math>\rightleftharpoons</math> 4,4-二甲基-5α-胆甾-8(9),14,24-三烯-3β-ol + 甲酸 + 3 NADP<sup>+</sup> + 4 H<sub>2</sub>O

[[File:Lanosterol Demethylation Pathway.png|380px|left|thumb|CYP51A1催化羊毛甾醇三次发生加氧反应，生成对应产物]]
==参考文献==
* {{reflist}}

{{Cytochrome P450}}
[[Category:EC 1.14.13]]
[[Category:细胞色素P450|51]]