查看“︁4-羟基丁酸脱氢酶”︁的源代码

{{enzyme
| Name = 4-羟基丁酸脱氢酶
| Systematic_name = 4-hydroxybutanoate:NAD<sup>+</sup> oxidoreductase
| Acronym = 
| Other_names = γ-hydroxybutyrate dehydrogenase
| EC_number = 1.1.1.61
| CAS_number = | IUBMB_EC_number = 1/1/1/61 | GO_code = 0047577 | image =
| width = 
| caption = 
}}
'''4-羟基丁酸脱氢酶'''（{{lang-en|4-hydroxybutyrate dehydrogenase}}，[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.61 1.1.1.61]{{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.61 |date=20200919190312 }}）是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]：

:[[4-羟基丁酸]] + [[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]] <math>\rightleftharpoons</math> [[琥珀酸半醛]] + NADH + [[氢离子|H<sup>+</sup>]]

4-羟基丁酸脱氢酶主要参与[[丁酸]]的[[代谢]]过程以及[[神经递质]][[γ-羟基丁酸]]的[[降解]]过程。

== 参考文献 ==
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{{cite journal | author = Nirenberg MW and Jakoby WB | year = 1960 | title = Enzymatic utilization of gamma-hydroxybutyric acid | url = https://archive.org/details/sim_journal-of-biological-chemistry_1960-04_235_4/page/954 | journal = J. Biol. Chem.  | volume = 235 | pages = 954–960 | pmid=14427301}}{{cite journal |author=Kaufman EE, Nelson T |title=An overview of gamma-hydroxybutyrate catabolism: the role of the cytosolic NADP(+)-dependent oxidoreductase EC 1.1.1.19 and of a mitochondrial hydroxyacid-oxoacid transhydrogenase in the initial, rate-limiting step in this pathway |journal=Neurochem. Res. |volume=16 |issue=9 |pages=965–974 |year=1991 |pmid=1784339 |doi=10.1007/BF00965839}}
{{refend}}

{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NADH依赖性酶]]
[[Category:未知结构的酶]]