查看“︁3-脱氢鞘氨酸还原酶”︁的源代码

{{enzyme
| Name = 3-脱氢鞘氨酸还原酶
| Systematic_name = D-''erythro''-dihydrosphingosine:NADP<sup>+</sup> 3-oxidoreductase
| Acronym = KDSR; FVT1
| Other_names = D-3-dehydrosphinganine reductase; D-3-oxosphinganine reductase; DSR; 3-oxosphinganine reductase; 3-oxosphinganine:NADPH oxidoreductase; D-3-oxosphinganine:B-NADPH oxidoreductase; follicular variant translocation protein 1
| EC_number = 1.1.1.102
| CAS_number = 37250-36-5
| IUBMB_EC_number = 1/1/1/102
| GO_code = 0047560
| image = 
| width = 
| caption = 
}}
{{PBB|geneid=2531}}
'''3-脱氢鞘氨酸还原酶'''（{{lang-en|3-dehydrosphinganine reductase}}，[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.102 1.1.1.102]{{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.102 |date=20190430072705 }}）也称为“'''滤泡变异易位蛋白1'''”，是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]：

:[[鞘氨酸]] + [[烟酰胺腺嘌呤二核苷酸磷酸|NADP]]<sup>+</sup> <math>\rightleftharpoons</math> 3-[[脱氢鞘氨酸]] + NADPH + [[氢离子|H<sup>+</sup>]]

3-脱氢鞘氨酸还原酶主要参与[[鞘脂]]（sphingolipid）的[[代谢]]过程。[[人类]]的3-脱氢鞘氨酸还原酶由[[18号染色体 (人类)|18号染色体]]上的[[基因]]KDSR编码，<ref name="pmid8417785">{{cite journal | author = Rimokh R, Gadoux M, Bertheas MF, Berger F, Garoscio M, Deleage G, Germain D, Magaud JP | title = FVT-1, a novel human transcription unit affected by variant translocation t(2;18)(p11;q21) of follicular lymphoma | journal = Blood | volume = 81 | issue = 1 | pages = 136–42 | pmid = 8417785 | pmc =  | doi =  |date=Feb 1993}}</ref><ref name="pmid15328338">{{cite journal | author = Kihara A, Igarashi Y | title = FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane | journal = J Biol Chem | volume = 279 | issue = 47 | pages = 49243–50 | pmid = 15328338 | pmc =  | doi = 10.1074/jbc.M405915200 |date=Nov 2004}}</ref><ref name="pmid17420465">{{cite journal | author = Krebs S, Medugorac I, Rother S, Strasser K, Forster M | title = A missense mutation in the 3-ketodihydrosphingosine reductase FVT1 as candidate causal mutation for bovine spinal muscular atrophy | journal = Proc Natl Acad Sci U S A | volume = 104 | issue = 16 | pages = 6746–51 | pmid = 17420465 | pmc = 1868895 | doi = 10.1073/pnas.0607721104 |date=Apr 2007}}</ref><ref name="pmid19027726">{{cite journal | author = Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U | title = The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative | journal = Chem Biol Interact | volume = 178 | issue = 1–3 | pages = 94–8 | pmid = 19027726 | pmc =  2896744| doi = 10.1016/j.cbi.2008.10.040 |date=Feb 2009}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FVT1 follicular lymphoma variant translocation 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2531| accessdate = }}</ref>这种蛋白仅在[[血细胞生成]]（haematopoiesis）[[组织 (生物学)|组织]]中少量[[基因表达|表达]]。

== 参考文献 ==
{{reflist}}
{{refbegin}}
* {{cite journal | author = Stoffel W, LeKim D, Sticht G | date = 1968 | title = Biosynthesis of dihydrosphingosine in vitro | journal = Hoppe. Seylers. Z. Physiol. Chem.  | volume = 349 | pages = 664-670  | pmid = 4386961 }}
* {{cite journal | author = Stoffel W, LeKim D, Sticht G | date = 1968 | title = Metabolism of sphingosine bases. 8. Distribution, isolation and properties of D-3-oxosphinganine reductase. Stereospecificity of the NADPH-dependent reaction of 3-oxodihydrospingosine (2-amino-1-hydroxyoctadecane-3-one) | journal = Hoppe. Seylers. Z. Physiol. Chem.  | volume = 349 | pages = 1637-1644  | pmid = 4387676 | doi = 10.1515/bchm2.1968.349.2.1637 }}
{{refend}}

== 扩展阅读 ==
{{refbegin}}
*{{cite journal  | author=Quintero-Ramos A |title=Assessment of five thrombophilic genetic polymorphisms among couples with habitual abortion |journal=Gaceta médica de México |volume=142 |issue= 2 |pages= 95–8 |year= 2006 |pmid= 16711541 |doi= | author2=Valdez-Vélázquez LL  | author3=Hernández G  | display-authors=3  | last4=Baltazar  | first4=LM  | last5=Padilla-Gutiérrez  | first5=JR  | last6=Valle  | first6=Y  | last7=Rodarte  | first7=K  | last8=Ortiz  | first8=R  | last9=Ortiz-Aranda  | first9=M  }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 | author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 | author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Wang J |title=Uterine tumor resembling ovarian sex cord tumor: report of a case with t(X;6)(p22.3;q23.1) and t(4;18)(q21.1;q21.3) |journal=Diagn. Mol. Pathol. |volume=12 |issue= 3 |pages= 174–80 |year= 2004 |pmid= 12960700 |doi= | author2=Blakey GL  | author3=Zhang L  | display-authors=3  | last4=Bane  | first4=B  | last5=Torbenson  | first5=M  | last6=Li  | first6=S  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 | author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Nacheva E |title=B-cell non-Hodgkin's lymphoma cell line (Karpas 1106) with complex translocation involving 18q21.3 but lacking BCL2 rearrangement and expression |journal=Blood |volume=84 |issue= 10 |pages= 3422–8 |year= 1994 |pmid= 7949096 |doi= | author2=Dyer MJ  | author3=Metivier C  | display-authors=3  | last4=Jadayel  | first4=D  | last5=Stranks  | first5=G  | last6=Morilla  | first6=R  | last7=Heward  | first7=JM  | last8=Holloway  | first8=T  | last9=O'Connor  | first9=S  }}
{{refend}}

{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NADPH依赖性酶]]
[[Category:未知结构的酶]]