查看“︁3-羟基-3-甲戊醛酸还原酶 (NADPH)”︁的源代码

{{enzyme
| Name = 3-羟基-3-甲戊醛酸还原酶 (NADPH)
| Systematic_name = (''R'')-mevalonate:NADP<sup>+</sup> oxidoreductase
| Acronym = 
| Other_names = mevaldate (reduced nicotinamide adenine dinucleotide phosphate) reductase; mevaldate reductase (NADPH<sub>2</sub>)
| EC_number = 1.1.1.33
| CAS_number = 9028-34-6
| IUBMB_EC_number = 1/1/1/33 
| GO_code = 0019726 
| image =
| width = 
| caption = 
}}
'''3-羟基-3-甲戊醛酸还原酶 (NADPH)'''（{{lang-en|mevaldate reductase (NADPH)}}，[[EC编号|EC]] 1.1.1.33<ref>[http://enzyme.expasy.org/EC/1.1.1.33 1.1.1.33]{{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.33 |date=20201128072636 }}</ref>）也称为“'''3-羟-3-甲戊醛酸还原酶 (NADPH)'''”，是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]：

:(''R'')-[[甲羟戊酸]] + [[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]] <math>\rightleftharpoons</math> [[3-羟基-3-甲戊醛酸]] + NADPH + [[氢离子|H<sup>+</sup>]]

有研究表明，3-羟基-3-甲戊醛酸还原酶还能氧化某些[[芳香醛]]，而其活性会被[[巴比妥类药物]]抑制。这些性质与{{EC number|1.1.1.2}}[[醇脱氢酶 (NADP+)|醇脱氢酶 (NADP<sup>+</sup>)]]的相似，两者可能是同一种酶。<ref>{{cite journal | author = Alan S. Beedle, Huw H. Rees, and Trevor W. Goodwin | title = Some properties and a suggested reclassification of mevaldate reductase | journal = Biochem J. | volume = 139 | issue = 1 | pages = 205-209 | <!--PMCID = PMC1166268--> | url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1166268/pdf/biochemj00585-0216.pdf|date=Apr 1974}}</ref>

== 参考文献 ==
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{{reflist}}
* {{cite book | author = Wolstenholme, G.E.W. and O'Connor, M. (Eds.), | title = CIBA Symposium on the Biosynthesis of Terpenes and Sterols, CIBA Symposium on the Biosynthesis of Terpenes and Sterols | location = London | year = 1959 | pages = 62-74 | language = en }}
* {{cite book | author = Jakoby, W.B. | title = Enzymatic Basis of Detoxication | volume = 1 | publisher = Academic Press | location = New York | year = 1980 | pages = 249-260 | language = en}}
{{refend}}

{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NADPH依赖性酶]]
[[Category:未知结构的酶]]