查看“︁3-羟基异丁酸脱氢酶”︁的源代码

{{PBB/11112}}
{{enzyme
| Name = 3-羟基异丁酸脱氢酶
| Systematic_name = 3-hydroxy-2-methylpropanoate:NAD<sup>+</sup> oxidoreductase
| Acronym = HIBADH
| Other_names = β-hydroxyisobutyrate dehydrogenase
| EC_number = 1.1.1.31
| CAS_number = 9028-39-1 | IUBMB_EC_number = 1/1/1/31 | GO_code = 0008442 | image = File:Protein_HIBADH_PDB_2gf2.png
| width = 
| caption = 3-羟基异丁酸脱氢酶结构（[[蛋白质数据库|PDB]] 2gf2）
}}
'''3-羟基异丁酸脱氢酶'''（{{lang-en|3-hydroxyisobutyrate dehydrogenase}}，[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.31 1.1.1.31]{{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.31 |date=20200914234330 }}）是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]：

:[[3-羟基-2-甲基丙酸]] + [[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]] <math>\rightleftharpoons</math> [[2-甲基-3-氧代丙酸]] + NADH + [[氢离子|H<sup>+</sup>]]

3-羟基异丁酸脱氢酶主要参与[[缬氨酸]]、[[亮氨酸]]和[[异亮氨酸]]的[[降解]]过程。

== 参考文献 ==
{{reflist}}
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*{{cite journal  |author=Gerhard DS |author2=Wagner L |author3=Feingold EA |display-authors=etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  |author=Hillier LW |author2=Fulton RS |author3=Fulton LA |display-authors=etal |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  |author=Scherer SW |author2=Cheung J |author3=MacDonald JR |display-authors=etal |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423  | pmc=2882961 }}
*{{cite journal  |author=Strausberg RL |author2=Feingold EA |author3=Grouse LH |display-authors=etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=  10.1101/gr.8.11.1097}}
*{{cite journal  |author=Hughes GJ |author2=Frutiger S |author3=Paquet N |display-authors=etal |title=Human liver protein map: update 1993. |journal=Electrophoresis |volume=14 |issue= 11 |pages= 1216–22 |year= 1994 |pmid= 8313870 |doi=10.1002/elps.11501401181  }}
*{{cite journal  |author=Rougraff PM |author2=Paxton R |author3=Kuntz MJ |display-authors=etal |title=Purification and characterization of 3-hydroxyisobutyrate dehydrogenase from rabbit liver. |journal=J. Biol. Chem. |volume=263 |issue= 1 |pages= 327–31 |year= 1988 |pmid= 3335502 |doi=  }}
*{{cite journal  |author=Rougraff PM |author2=Zhang B |author3=Kuntz MJ,|display-authors=etal |title=Cloning and sequence analysis of a cDNA for 3-hydroxyisobutyrate dehydrogenase. Evidence for its evolutionary relationship to other pyridine nucleotide-dependent dehydrogenases. |journal=J. Biol. Chem. |volume=264 |issue= 10 |pages= 5899–903 |year= 1989 |pmid= 2647728 |doi=  }}
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{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NADH依赖性酶]]
[[Category:已知结构的酶]]