查看“︁3-氧酰基-(酰基载体蛋白)还原酶”︁的源代码

{{DISPLAYTITLE:3-氧酰基-[酰基载体蛋白]还原酶}}
{{enzyme
| Name = 3-氧酰基-[酰基载体蛋白]还原酶
| Systematic_name = (3''R'')-3-hydroxyacyl-[acyl-carrier protein]:NADP<sup>+</sup> oxidoreductase
| Acronym = 
| Other_names = β-ketoacyl-[acyl-carrier protein](ACP) reductase; β-ketoacyl acyl carrier protein (ACP) reductase; β-ketoacyl reductase; β-ketoacyl thioester reductase; β-ketoacyl-ACP reductase; β-ketoacyl-acyl carrier protein reductase; 3-ketoacyl acyl carrier protein reductase; NADPH-specific 3-oxoacyl-[acylcarrier protein]reductase; 3-oxoacyl-[ACP]reductase
| EC_number = 1.1.1.100
| CAS_number = 37250-34-3
| IUBMB_EC_number = 1/1/1/100
| GO_code = 0004316
| image = 
| width = 
| caption = 
}}
'''3-氧酰基-[酰基载体蛋白]还原酶'''（{{lang-en|3-oxoacyl-[acyl-carrier-protein] reductase}}，[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.100 1.1.1.100]{{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.100 |date=20210122010214 }}），是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]：

:(3''R'')-3-羟酰基-<nowiki>[</nowiki>[[酰基载体蛋白]]<nowiki>]</nowiki> + [[烟酰胺腺嘌呤二核苷酸磷酸|NADP]]<sup>+</sup> <math>\rightleftharpoons</math> 3-氧酰基-[酰基载体蛋白] + NADPH + [[氢离子|H<sup>+</sup>]]

3-氧酰基-[酰基载体蛋白]还原酶主要参与[[多不饱和脂肪酸]]等[[脂肪酸]]的[[生物合成]]过程。这种酶在以不同[[辅酶A]][[衍生物]]为[[底物]]时对不同酰基载体蛋白衍生物表现处明显的选择性。

== 结构研究 ==
至2007年，3-氧酰基-[酰基载体蛋白]还原酶已有21种[[蛋白质三级结构|三级结构]]被解析，它们对应的[[蛋白质数据库]]编号分别为：{{PDB link|1I01}}、{{PDB link|1O5I}}、{{PDB link|1Q7B}}、{{PDB link|1Q7C}}、{{PDB link|1ULS}}、{{PDB link|1UZL}}、{{PDB link|1UZM}}、{{PDB link|1UZN}}、{{PDB link|2A4K}}、{{PDB link|2B4Q}}、{{PDB link|2C07}}、{{PDB link|2FR0}}、{{PDB link|2FR1}}、{{PDB link|2NM0}}、{{PDB link|2NTN}}、{{PDB link|2P68}}、{{PDB link|2PFF}}、{{PDB link|2PH3}}、{{PDB link|2PNF}}、{{PDB link|2UVD}}及{{PDB link|2Z5L}}。

== 参考文献 ==
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{{refbegin}}
* {{cite journal | author = Prescott DJ, Vagelos PR | date = 1972 | title = Acyl carrier protein | journal = Adv. Enzymol. Relat. Areas. Mol. Biol.  | volume = 36 | pages = 269-311  | pmid = 4561013 }}
* {{cite journal | author = Shimakata T, Stumpf PK | date = 1982 | title = Purification and characterizations of beta-Ketoacyl-[acyl-carrier-protein] reductase, beta-hydroxyacyl-[acylcarrier-protein] dehydrase, and enoyl-[acyl-carrier-protein] reductase from ''Spinacia oleracea'' leaves | journal = Arch. Biochem. Biophys.  | volume = 218 | pages = 77-91  | pmid = 6756317 | issue = 1 | doi=10.1016/0003-9861(82)90323-X}}
* {{cite journal | author = Toomey RE, Wakil SJ | date = 1966 | title = Studies on the mechanism of fatty acid synthesis. XV. Preparation and general properties of beta-ketoacyl acyl carrier protein reductase from ''Escherichia coli'' | journal = Biochim. Biophys. Acta.  | volume = 116 | pages = 189-197  | pmid = 4381013 | issue = 2 | doi=10.1016/0005-2760(66)90001-4}}
{{refend}}

{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NADPH依赖性酶]]
[[Category:已知结构的酶]]