查看“︁3α-羟基类固醇脱氢酶 (B特异性)”︁的源代码

{{enzyme
| Name = 3α-羟基类固醇脱氢酶 (B特异性)
| Systematic_name = 3α-hydroxysteroid:NAD(P)<sup>+</sup> oxidoreductase (B-specific)
| Acronym = 
| Other_names = hydroxyprostaglandin dehydrogenase; 3α-hydroxysteroid oxidoreductase; sterognost 3α
| EC_number = 1.1.1.50
| CAS_number = 9028-56-2 | IUBMB_EC_number = 1/1/1/50 | GO_code = 0047042 | image =
| width = 
| caption = 
}}
'''3α-羟基类固醇脱氢酶 (B特异性)'''（{{lang-en|3α-hydroxysteroid dehydrogenase (B-specific)}}，[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.50 1.1.1.50]{{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.50 |date=20200813011237 }}）是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]：

:[[雄甾酮]] + [[烟酰胺腺嘌呤二核苷酸|NAD]]([[烟酰胺腺嘌呤二核苷酸磷酸|P]])<sup>+</sup> <math>\rightleftharpoons</math> 5α-[[雄甾烷]]-3,17-二酮 + NAD(P)H + [[氢离子|H<sup>+</sup>]]

3α-羟基类固醇脱氢酶 (B特异性)主要参与三条[[代谢|代谢途径]]：[[胆汁酸]]的[[生物合成]]、[[C21类固醇激素]]的代谢以及[[雄激素]]和[[雌激素]]的代谢。

== 参考文献 ==
{{reflist}}
{{refbegin}}
* {{cite journal | author = JARABAK J, TALALAY P | year = 1960 | title = Stereospecificity of hydrogen transfer by pyridine nucleotide-linked hydroxysteroid dehydrogenases | url = https://archive.org/details/sim_journal-of-biological-chemistry_1960-07_235_7/page/2147 | journal = J. Biol. Chem.  | volume = 235 | pages = 2147–51  | pmid = 14406805 }}{{Wordbreak}}* {{cite journal | author = KOCHAKIAN CD, CARROLL BR, UHRI B | year = 1957 | title = Comparisons of the oxidation of C19-hydroxysteroids by guinea pig liver homogenates | journal = J. Biol. Chem.  | volume = 224 | pages = 811–8  | pmid = 13405910 | issue = 2 }}{{Wordbreak}}* {{cite journal | author = Marcus PI and Talalay P | year = 1956 | title = Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases | journal = J. Biol. Chem.  | volume = 218 | issue = 2 | pages = 661–674 | pmid=13295221}}{{Wordbreak}}* {{cite journal | author = Penning TM, Sharp RB | year = 1987 | title = Prostaglandin dehydrogenase activity of purified rat liver 3 alpha-hydroxysteroid dehydrogenase | journal = Biochem. Biophys. Res. Commun.  | volume = 148 | pages = 646–52  | pmid = 3479982 | doi = 10.1016/0006-291X(87)90925-9 | issue = 2 }}
{{refend}}

{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NADH依赖性酶]]
[[Category:NADPH依赖性酶]]
[[Category:已知结构的酶]]