查看“︁3α(17β)-羟基类固醇脱氢酶 (NAD+)”︁的源代码

{{DISPLAYTITLE|3α(17β)-羟基类固醇脱氢酶 (NAD<sup>+</sup>)}}
{{enzyme
| Name = 3α(17β)-羟基类固醇脱氢酶 (NAD<sup>+</sup>)
| Systematic_name = 17β-hydroxysteroid:NAD<sup>+</sup> 17-oxidoreductase
| Acronym = 17β-HSD
| Other_names = 17-ketoreductase
| EC_number = 1.1.1.63
| CAS_number = 9028-62-0 | IUBMB_EC_number = 1/1/1/63 | GO_code = 0050327 | image =
| width = 
| caption = 
}}
'''3α(17β)-羟基类固醇脱氢酶 (NAD<sup>+</sup>)'''（{{lang-en|3α(17β)-Hydroxysteroid dehydrogenase (NAD<sup>+</sup>)}}，{{EC number|1.1.1.239}}），原称作'''睾酮17β-脱氢酶'''（{{EC number|1.1.1.63}}），是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]：

:[[睾酮]] + [[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]] <math>\rightleftharpoons</math> [[雄烯二酮]] + NADH + [[氢离子|H<sup>+</sup>]]

3α(17β)-羟基类固醇脱氢酶 (NAD<sup>+</sup>)主要参与[[雄激素]]和[[雌激素]][[代谢]]过程。

== 参考文献 ==
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* {{cite journal | author = ENDAHL GL, KOCHAKIAN CD, HAMM D | date = 1960 | title = Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine nucleotide-specific 17 beta-hydroxy-(testosterone) dehydrogenase of guinea pig liver | url = https://archive.org/details/sim_journal-of-biological-chemistry_1960-10_235_10/page/2792 | journal = J. Biol. Chem.  | volume = 235 | pages = 2792–6  | pmid = 13696735 }}{{wordbreak}}* {{cite journal | author = SWEAT ML, SAMUELS LT, LUMRY R | date = 1950 | title = Preparation and characterization of the enzyme which converts testosterone to androstenedione | journal = J. Biol. Chem.  | volume = 185 | pages = 75–84  | pmid = 15436478 | issue = 1 }}{{wordbreak}}* {{cite journal | author = Villee CA and Spencer JM | date = 1960 | title = Some properties of the pyridine nucleotide-specific 17beta-hydroxy steroid dehydrogenase of guinea pig liver | url = https://archive.org/details/sim_journal-of-biological-chemistry_1960-12_235_12/page/3615 | journal = J. Biol. Chem.  | volume = 235 | pages = 3615–3619 | pmid=13781425}}
{{refend}}

{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NADH依赖性酶]]
[[Category:未知结构的酶]]