查看“︁鲨烯-藿烯环化酶”︁的源代码

{{Infobox enzyme
| Name = Squalene-hopene cyclase
| EC_number = 5.4.99.17
| CAS_number = 76600-69-6
| IUBMB_EC_number = 5/4/99/17 or 4/2/1/129
| GO_code = 
| image = 2sqc.png
| width = 
| caption = 鲨烯-藿烯环化酶二聚体的[[晶体结构]]
}}
'''鲨烯-藿烯环化酶'''（{{lang-en|Squalene-hopene cyclase}}，缩写'''SHC'''，{{EC number|5.4.99.17}}）或称作'''藿烷-22-醇水裂解酶'''（hopan-22-ol hydro-lyase，{{EC number|4.2.1.129}}）属于原核生物中生成五环[[三萜]]的环化/变位酶家族，能催化下列两种反应，生成[[藿烯]]或[[藿烷-22-醇]]，两种产物的比例为5比1<ref>{{cite journal | vauthors = Hoshino T, Sato T | title = Squalene-hopene cyclase: catalytic mechanism and substrate recognition | journal = Chemical Communications | volume =  | issue = 4 | pages = 291–301 | date = February 2002 | pmid = 12120044 | doi = 10.1039/b108995c }}</ref><ref>{{cite journal | vauthors = Hoshino T, Nakano S, Kondo T, Sato T, Miyoshi A | title = Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring | journal = Organic & Biomolecular Chemistry | volume = 2 | issue = 10 | pages = 1456–70 | date = May 2004 | pmid = 15136801 | doi = 10.1039/b401172d }}</ref><ref>{{cite journal | vauthors = Sato T, Kouda M, Hoshino T | title = Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius | journal = Bioscience, Biotechnology, and Biochemistry | volume = 68 | issue = 3 | pages = 728–38 | date = March 2004 | pmid = 15056909 | doi = 10.1271/bbb.68.728 }}</ref><ref name="Reinert, D.J., Balliano, G. and Schulz, G.E. 2004 121–126">{{cite journal | vauthors = Reinert DJ, Balliano G, Schulz GE | title = Conversion of squalene to the pentacarbocyclic hopene | journal = Chemistry & Biology | volume = 11 | issue = 1 | pages = 121–6 | date = January 2004 | pmid = 15113001 | doi = 10.1016/j.chembiol.2003.12.013 }}</ref><ref name="Pearson, A., Budin, M., and Brocks, J. 2003 15352–15357">{{cite journal | vauthors = Pearson A, Budin M, Brocks JJ | title = Phylogenetic and biochemical evidence for sterol synthesis in the bacterium Gemmata obscuriglobus | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 26 | pages = 15352–7 | date = December 2003 | pmid = 14660793 | pmc = 307571 | doi = 10.1073/pnas.2536559100 }}</ref>：

: [[鲨烯]] <math>\rightleftharpoons</math> 22(29)-藿烯

: [[鲨烯]] + H<sub>2</sub>O <math>\rightleftharpoons</math> 藿烷-22-醇


==参考文献==
{{reflist}}
==外部链接==
* {{MeshName|Squalene-hopene+cyclase}}
{{变位酶}}
[[Category:EC 5.4.99]]