查看“︁高异柠檬酸脱氢酶”︁的源代码

{{enzyme
| Name = 高异柠檬酸脱氢酶
| Systematic_name = (1''R'',2''S'')-1-hydroxybutane-1,2,4-tricarboxylate:NAD<sup>+</sup> oxidoreductase (decarboxylating)
| Acronym = HICDH
| Other_names = 2-hydroxy-3-carboxyadipate dehydrogenase; 3-carboxy-2-hydroxyadipate dehydrogenase; homoisocitric dehydrogenase; (–)-1-hydroxy-1,2,4-butanetricarboxylate:NAD<sup>+</sup> oxidoreductase (decarboxylating); 3-carboxy-2-hydroxyadipate:NAD<sup>+</sup> oxidoreductase (decarboxylating)
| EC_number = 1.1.1.87
| CAS_number = 37250-23-0 | IUBMB_EC_number = 1/1/1/87 | GO_code = 0047046
| image = 4yb4.jpg
| width = 270
| caption = 
}}
'''高异柠檬酸脱氢酶'''（{{lang-en|homoisocitrate dehydrogenase}}，[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.87 1.1.1.87] {{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.87 |date=20201118094427 }}）是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[高异柠檬酸]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]：

:(1''R'',2''S'')-1-[[羟基]][[丁烷]]-1,2,4-三[[羧酸]] + [[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]] <math>\rightleftharpoons</math> [[α-酮己二酸]] + [[二氧化碳|CO<sub>2</sub>]] + NADH

高异柠檬酸脱氢酶主要参与[[真菌]]的[[赖氨酸]][[生物合成]]过程。<ref>{{cite journal | author = Zabriskie TM, Jackson MD | date = 2000 | title = Lysine biosynthesis and metabolism in fungi | journal = Nat. Prod. Rep.  | volume = 17 | pages = 85–97  | pmid = 10714900 | doi = 10.1039/a801345d | issue = 1 }}</ref>

== 参考文献 ==
{{reflist}}
{{refbegin}}
* {{cite journal | author = Strassman M, Ceci LN | date = 1965 | title = Enzymatic formation of alpha-ketoadipic acid from homoisocitric acid | journal = J. Biol. Chem.  | volume = 240 | pages = 4357–61  | pmid = 4284830 | issue = 11 }}{{wordbreak}}* {{cite journal | author = Rowley B, Tucci AF | date = 1970 | title = Homoisocitric dehydrogenase from yeast | journal = Arch. Biochem. Biophys.  | volume = 141 | pages = 499–510  | pmid = 4395693 | doi = 10.1016/0003-9861(70)90167-0 | issue = 2 }}
{{refend}}

{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NADH依赖性酶]]
[[Category:已知结构的酶]]