查看“︁醛糖1-脱氢酶 (NAD+)”︁的源代码

{{DISPLAYTITLE:醛糖1-脱氢酶 (NAD<sup>+</sup>)}}
{{enzyme
| Name = 醛糖1-脱氢酶 (NAD<sup>+</sup>)
| Systematic_name = <small>D</small>-aldose:NAD<sup>+</sup> 1-oxidoreductase
| Acronym = 
| Other_names = aldose dehydrogenase; D-aldohexose dehydrogenase; aldose 1-dehydrogenase
| EC_number = 1.1.1.121
| CAS_number = 9076-61-3
| IUBMB_EC_number = 1/1/1/121
| GO_code = 0047640
| image = 
| width = 
| caption = 
}}
'''醛糖1-脱氢酶 (NAD<sup>+</sup>)'''（{{lang-en|aldose 1-dehydrogenase (NAD<sup>+</sup>)}}，[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.121 1.1.1.121] {{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.121 |date=20190505113305 }}），是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]，其作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]：

:[[D-醛糖|<small>D</small>-醛糖]] + [[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]] <math>\rightleftharpoons</math> [[醛糖酸内酯|<small>D</small>-醛糖酸内酯]] + NADH + [[氢离子|H<sup>+</sup>]]

醛糖1-脱氢酶 (NAD<sup>+</sup>)也能催化[[D-葡萄糖|<small>D</small>-葡萄糖]]、2-脱氧-<small>D</small>-葡萄糖、6-脱氧-<small>D</small>-葡萄糖、[[D-半乳糖|<small>D</small>-半乳糖]]、6-脱氧-<small>D</small>-半乳糖、2-脱氧-<small>L</small>-阿拉伯糖以及[[D-木糖|<small>D</small>-木糖]]等发生反应，并会受到[[1,10-邻氮二菲]]、[[2,3-苯并呋喃]]、[[己二烯雌二醇]]、[[吲唑]]、[[吲哚]]等[[有机分子]]及[[银离子|Ag<sup>+</sup>]]、[[钙离子|Ca<sup>2+</sup>]]等[[阳离子]]的抑制。<ref>{{cite journal | author = Asada Y, Endo S, Inoue Y, Mamiya H, Hara A, Kunishima N, Matsunaga T | date = 2009 | title = Biochemical and structural characterization of a short-chain dehydrogenase/reductase of ''Thermus thermophilus'' HB8: a hyperthermostable aldose-1-dehydrogenase with broad substrate specificity. | journal = Chem. Biol. Interact | volume = 178 | pages = 117-126 | pmid = 18926808 | issue = 1-3 | url = http://www.ncbi.nlm.nih.gov/pubmed/18926808 | access-date = 2013-07-12 | archive-date = 2017-09-07 | archive-url = https://web.archive.org/web/20170907071049/https://www.ncbi.nlm.nih.gov/pubmed/18926808 }}</ref><ref>{{cite journal | author = Dahms AS, Anderson RL | date = 1972 | title = <small>D</small>-Fucose metabolism in a pseudomonad. I. Oxidation of <small>D</small>-fucose to <small>D</small>-fucono- -lactone by a <small>D</small>-aldohexose dehydrogenase | journal = J. Biol. Chem. | volume = 247 | pages = 2222-2227 | pmid = 4335867 | issue = 7 | url = http://www.ncbi.nlm.nih.gov/pubmed/4335867 | access-date = 2013-07-12 | archive-date = 2016-05-29 | archive-url = https://web.archive.org/web/20160529031759/http://www.ncbi.nlm.nih.gov/pubmed/4335867/ }}</ref><ref>{{cite journal | author = Nishiya Y, Tamura N, Tamura T | date = 2004 | title = Analysis of bacterial glucose dehydrogenase homologs from thermoacidophilic archaeon ''Thermoplasma acidophilum'': finding and characterization of aldohexose dehydrogenase | journal = Biosci Biotechnol Biochem. | volume = 68 | pages = 2451-2456 | pmid = 4335867 | issue = 12 | url = http://www.ncbi.nlm.nih.gov/pubmed/15618614 | access-date = 2013-07-12 | archive-date = 2019-06-14 | archive-url = https://web.archive.org/web/20190614081129/https://www.ncbi.nlm.nih.gov/pubmed/15618614 | dead-url = no }}</ref>

== 参考文献 ==
{{reflist}}
{{refbegin}}
* {{cite journal | author = Cline AL, Hu AS | date = 1965 | title = The isolation of three sugar dehydrogenases from a {{sic|psuedomonad}} | journal = J. Biol. Chem.  | volume = 240 | pages = 4488–92  | pmid = 5845847 | issue = 11 }}
* {{cite journal | author = Cline AL, Hu AS | date = 1965 | title = Enzymatic characterization and comparison of three sugar dehydrogenases from a pseudomonad | journal = J. Biol. Chem.  | volume = 240 | pages = 4493–7  | pmid = 5845848 | issue = 11 }}
* {{cite journal | author = Cline AL, Hu AS | date = 1965 | title = Some physical properties of three sugar dehydrogenases from a pseudomonad | journal = J. Biol. Chem.  | volume = 240 | pages = 4498–502  | pmid = 5845849 | issue = 11 }}
{{refend}}

{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NADH依赖性酶]]
[[Category:未知结构的酶]]