查看“︁酮醇酸还原异构酶”︁的源代码

{{enzyme
| Name = 酮醇酸还原异构酶
| Systematic_name = (''R'')-2,3-dihydroxy-3-methylbutanoate:NADP<sup>+</sup> oxidoreductase (isomerizing)
| Acronym = KARI
| Other_names = dihydroxyisovalerate dehydrogenase (isomerizing); acetohydroxy acid isomeroreductase; ketol acid reductoisomerase; α-keto-β-hydroxylacyl reductoisomerase; 2-hydroxy-3-keto acid reductoisomerase; acetohydroxy acid reductoisomerase; acetolactate reductoisomerase; dihydroxyisovalerate (isomerizing) dehydrogenase; isomeroreductase; reductoisomerase
| EC_number = 1.1.1.86
| CAS_number = 9075-02-9 | IUBMB_EC_number = 1/1/1/86 | GO_code = 0004455 
| image = 4tsk.jpg
| width = 270
| caption = 
}}
'''酮醇酸还原异构酶'''（{{lang-en|ketol-acid reductoisomerase}}，[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.86 1.1.1.86] {{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.86 |date=20200821210940 }}）是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]：

:(''R'')-2,3-二[[羟基]]-3-[[甲基]][[丁酸]] + [[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]] <math>\rightleftharpoons</math> (''S'')-2-羟基-2-甲基-3-[[氧代丁酸]] + NADPH + [[氢离子|H<sup>+</sup>]]

酮醇酸还原异构酶还能将2-乙酰-2-羟基丁酸催化转化为2,3-二羟基-3-甲基[[戊酸]]。

== 参考文献 ==
{{reflist}}
{{refbegin}}
* {{cite journal | author = Arfin SM, Umbarger HE | date = 1969 | title = Purification and properties of the acetohydroxy acid isomeroreductase of Salmonella typhimurium | journal = J. Biol. Chem.  | volume = 244 | pages = 1118–27  | pmid = 4388025 | issue = 5 }}{{wordbreak}}* {{cite journal | author = Hill RK, Sawada S and Arfin SM | date = 1979 | title = Stereochemistry of valine and isoleucine biosynthesis. IV Synthesis, configuration, and enzymatic specificity of alpha-acetolactate and alpha-aceto-alpha-hydroxybutyrate | journal = Bioorg. Chem.  | volume = 8 | pages = 175–189 | doi = 10.1016/0045-2068(79)90003-8 | issue = 2 }}{{wordbreak}}* {{cite journal | author = Kiritani K, Narise S and Wagner RP | date = 1966 | title = The reductoisomerase of ''Neurospora crassa'' | journal = J. Biol. Chem.  | volume = 241 | pages = 2047–2051 }}{{wordbreak}}* {{cite journal | author = Satyanarayana T, Radhakrishnan AN | date = 1965 | title = Biosynthesis of valine and isoleucine in plants. 3. Reductoisomerase of ''Phaseolus radiatus'' | journal = Biochim. Biophys. Acta.  | volume = 110 | pages = 380–8  | pmid = 5866387 | issue = 2 }}
{{refend}}

{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NADPH依赖性酶]]
[[Category:已知结构的酶]]