查看“︁超敏性”︁的源代码

[[File:Ultrasensitivity.png|thumb|具有超敏性的反应体系（实线）与符合[[米-门二氏动力学|米氏动力学]]的反应体系对刺激（横轴）产生的反应强度（纵轴）简图]]
'''超敏性'''（{{lang|en|ultrasensitivity}}）在[[分子生物学]]中是指某一体系对刺激的敏感性高，能产生强于[[米-门二氏动力学|米氏动力学]]理论值的反应。具有超敏性的反应体系在刺激强度低时反应强度也低，但刺激强度超过某一阈值后，反应强度会迅速升高<ref>{{Cite journal|title=Bigger, Better, Faster: Principles and Models of AKAP Anchoring Protein Signaling|url=http://journals.lww.com/00005344-201111000-00003|last=Greenwald|first=Eric C.|last2=Saucerman|first2=Jeffrey J.|date=2011-11|journal=Journal of Cardiovascular Pharmacology|issue=5|doi=10.1097/FJC.0b013e31822001e3|volume=58|pages=462–469|language=en|issn=0160-2446|pmc=3173587|pmid=21562426}}</ref>。

超敏性反应体系的反应强度可以通过以下式子（[[希尔方程_(生物化学)|希尔方程]]）计算，确定了希尔係數(n)就能对一个具超敏性的反应体系进行定量：
:<math chem display="inline">\ce{Response} = {Stimulus^n \over (\ce{EC50}^n+Stimulus^n)}</math>

超敏性是[[细胞]]从一个[[细胞周期]]进入另一个细胞周期的分子机制之一<ref>{{Cite journal|title=Quantification of the glycogen cascade system: the ultrasensitive responses of liver glycogen synthase and muscle phosphorylase are due to distinctive regulatory designs|url=https://tbiomed.biomedcentral.com/articles/10.1186/1742-4682-2-19|last=Mutalik|first=Vivek K|last2=Venkatesh|first2=Kv|date=2005-12|journal=Theoretical Biology and Medical Modelling|issue=1|doi=10.1186/1742-4682-2-19|volume=2|pages=19|language=en|issn=1742-4682|pmc=1180476|pmid=15907212|access-date=2021-11-10|archive-date=2022-06-22|archive-url=https://web.archive.org/web/20220622235159/https://tbiomed.biomedcentral.com/articles/10.1186/1742-4682-2-19}}</ref><ref name="Ferrell">{{Cite journal|title=How regulated protein translocation can produce switch-like responses|url=https://pubmed.ncbi.nlm.nih.gov/9868363|last=Ferrell|first=J. E.|date=1998-12|journal=Trends in Biochemical Sciences|issue=12|doi=10.1016/s0968-0004(98)01316-4|volume=23|pages=461–465|issn=0968-0004|pmid=9868363|access-date=2021-11-10|archive-date=2022-07-12|archive-url=https://web.archive.org/web/20220712032232/https://pubmed.ncbi.nlm.nih.gov/9868363/}}</ref>。

==参见==
*[[米-门二氏动力学]]
*[[希尔方程 (生物化学)]]

==参考文献==
{{reflist}}
{{Biochem-stub}}

[[Category:生物化学]]