查看“︁葡萄糖1-脱氢酶”︁的源代码

{{about|两种辅酶都适用的葡萄糖1-脱氢酶|以NAD<sup>+</sup>作为辅酶的酶|葡萄糖1-脱氢酶 (NAD+)|以NADP<sup>+</sup>作为辅酶的酶|葡萄糖1-脱氢酶 (NADP+)}}
{{enzyme
| Name = 葡萄糖1-脱氢酶
| Systematic_name = β-<small>D</small>-glucose:NAD(P)<sup>+</sup> 1-oxidoreductase
| Acronym = 
| Other_names = <small>D</small>-glucose dehydrogenase (NAD(P)); hexose phosphate dehydrogenase
| EC_number = 1.1.1.47
| CAS_number = 9028-53-9 
| IUBMB_EC_number = 1/1/1/47 
| GO_code = 0047936 
| image = 1spx.jpg
| width = 270
| caption = Glucose dehydrogenase tetramer, Caenorhabditis Elegans
}}
'''葡萄糖1-脱氢酶'''（{{lang-en|glucose 1-dehydrogenase}}，[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.47 1.1.1.47] {{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.47 |date=20200919184817 }}）是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]：

:β-[[D-葡萄糖|<small>D</small>-葡萄糖]] + [[烟酰胺腺嘌呤二核苷酸|NAD]]([[烟酰胺腺嘌呤二核苷酸磷酸|P]])<sup>+</sup> <math>\rightleftharpoons</math> <small>D</small>-[[葡萄糖酸]]-1,5-[[内酯]] + NAD(P)H + [[氢离子|H<sup>+</sup>]]

葡萄糖1-脱氢酶主要参与[[磷酸戊糖途径]]。这种酶也能氧化[[D-木糖|<small>D</small>-木糖]]。

== 结构研究 ==
至2007年末，这类酶已被解析出9个[[三级结构]]，其[[蛋白质数据库|PDB]]编码分别为{{PDB link|1G6K}}、{{PDB link|1GCO}}、{{PDB link|1GEE}}、{{PDB link|1RWB}}、{{PDB link|1SPX}}、{{PDB link|2B5V}}、{{PDB link|2B5W}}、{{PDB link|2CD9}}以及{{PDB link|2CDA}}。

== 参考文献 ==
{{reflist}}
{{refbegin}}
* {{cite journal | author = K, Rick W, Staudinger HJ | year = 1975 | title = A glucose dehydrogenase for the determination of glucose concentrations in body fluids (author's transl) | journal = Z. Klin. Chem. Klin. Biochem.  | volume = 13 | pages = 101–7  | pmid = 810982 | issue = 3 }}
* {{cite journal | author = Brink NG | year = 1953 | title = Beef liver glucose dehydrogenase. 1. Purification and properties | journal = Acta Chem. Scand.  | volume = 7 | pages = 1081–1089 | doi = 10.3891/acta.chem.scand.07-1081 | last2 = Miettinen | first2 = Jorma K. | last3 = Olsen | first3 = John | last4 = Virtanen | first4 = Artturi I. | last5 = Sörensen | first5 = Nils Andreas }}
* {{cite journal | author = Pauly HE and Pfleiderer G | year = 1976 | title = D-Glucose dehydrogenase from ''Bacillus megaterium'' M 1286: purification, properties and structure | journal = Hoppe-Seyler's Z. Physiol. Chem.  | volume = 356 | pages = 1613–1623 | pmid=2530 | issue = 10}}
* {{cite journal | author = Strecker HJ, Korkes S | year = 1952 | title = Glucose dehydrogenase | url = https://archive.org/details/sim_journal-of-biological-chemistry_1952-06_196_2/page/769 | journal = J. Biol. Chem.  | volume = 196 | pages = 769–84  | pmid = 12981017 | issue = 2 }}
* {{cite journal | author = Thompson RE, Carper WR | year = 1970 | title = Glucose dehydrogenase from pig liver. I. Isolation and purification | journal = Biochim. Biophys. Acta.  | volume = 198 | pages = 397–406  | pmid = 4392298 | issue = 3 }}
{{refend}}

{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NADH依赖性酶]]
[[Category:NADPH依赖性酶]]
[[Category:已知结构的酶]]