查看“︁萘普生铜”︁的源代码

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| Name           = 萘普生铜
| ImageFile      = Copper naproxen.jpg
| ImageFile1     = Copper naproxen.svg
| ImageCaption   = 玻璃瓶中萘普生铜样品
| OtherNames     = 6-甲氧基-a-甲基-2-萘乙酸铜
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| Section2       = {{Chembox Properties 
| C = 28 | H = 26 | Cu = 1 | O = 6
| Appearance = 绿色晶体
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| SolubleOther = 溶于[[甲醇]]、[[1,4-二𫫇烷]]、<ref name="Melnik" />[[二甲基亚砜]]、[[2,5-二甲基呋喃]]<ref name="Dimiza" />
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| Section8       = {{Chembox Related
| OtherAnions = 
| OtherCompounds = [[乙酰水杨酸铜]]<br />[[布洛芬铜]]
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'''萘普生铜'''（英语：Copper naproxen）是二价[[铜]]与[[抗炎药]][[萘普生]][[螯合物|螯合]]的化学[[络合物]]。<ref name="Melnik" />萘普生等[[非甾体抗炎药]]的铜络合物已被证明比基础药物具有更强的抗炎特性。<ref>{{Citation |last=Sorenson |first=John R.J. |title=6 Copper Complexes Offer a Physiological Approach to Treatment of Chronic Diseases |date=1989 |url=https://linkinghub.elsevier.com/retrieve/pii/S0079646808702467 |series=Progress in Medicinal Chemistry |volume=26 |pages=437–568 |publisher=Elsevier |language=en |doi=10.1016/s0079-6468(08)70246-7 |isbn=978-0-444-81038-0 |access-date=2022-04-10 |archive-date=2019-04-01 |archive-url=https://web.archive.org/web/20190401024020/https://linkinghub.elsevier.com/retrieve/pii/S0079646808702467 |dead-url=no }}</ref><ref name="Dimiza">{{Cite journal |last1=Dimiza |first1=Filitsa |last2=Perdih |first2=Franc |last3=Tangoulis |first3=Vassilis |last4=Turel |first4=Iztok |last5=Kessissoglou |first5=Dimitris P. |last6=Psomas |first6=George |date=March 2011 |title=Interaction of copper(II) with the non-steroidal anti-inflammatory drugs naproxen and diclofenac: Synthesis, structure, DNA- and albumin-binding |url=https://linkinghub.elsevier.com/retrieve/pii/S0162013410002060 |journal=Journal of Inorganic Biochemistry |language=en |volume=105 |issue=3 |pages=476–489 |doi=10.1016/j.jinorgbio.2010.08.013 |access-date=2023-10-07 |archive-date=2022-11-17 |archive-url=https://web.archive.org/web/20221117135517/https://linkinghub.elsevier.com/retrieve/pii/S0162013410002060 |dead-url=no }}</ref>

萘普生铜可以以一[[水合物]]的形式存在，并且可以与其他[[有机分子]]（例如[[烟醇]]、[[3-甲基吡啶]]和[[咖啡因]]）形成络合物。<ref name="Melnik" /><ref>{{Cite journal |last1=Caglar |first1=Sema |last2=Adiguzel |first2=Ekrem |last3=Sariboga |first3=Bahtiyar |last4=Temel |first4=Ersin |last5=Buyukgungor |first5=Orhan |date=2014-02-16 |title=Mono and dinuclear copper(II) naproxenato complexes containing 3-picoline and 4-picoline: synthesis, structure, properties, catechol oxidase, and antimicrobial activities |url=https://www.tandfonline.com/doi/full/10.1080/00958972.2014.891198 |journal=Journal of Coordination Chemistry |language=en |volume=67 |issue=4 |pages=670–683 |doi=10.1080/00958972.2014.891198 |s2cid=96991445 |issn=0095-8972 |access-date=2023-10-07 |archive-date=2022-04-11 |archive-url=https://web.archive.org/web/20220411000758/https://www.tandfonline.com/doi/full/10.1080/00958972.2014.891198 |dead-url=no }}</ref><ref>{{Cite journal |last1=Abuhijleh |first1=A. Latif |last2=Khalaf |first2=Juhienah |date=September 2010 |title=Copper (II) complexes of the anti-inflammatory drug naproxen and 3-pyridylmethanol as auxiliary ligand. Characterization, superoxide dismutase and catecholase – mimetic activities |url=https://linkinghub.elsevier.com/retrieve/pii/S0223523410003715 |journal=European Journal of Medicinal Chemistry |language=en |volume=45 |issue=9 |pages=3811–3817 |doi=10.1016/j.ejmech.2010.05.031 |pmid=20605277 |access-date=2023-10-07 |archive-date=2023-04-17 |archive-url=https://web.archive.org/web/20230417175832/https://linkinghub.elsevier.com/retrieve/pii/S0223523410003715 |dead-url=no }}</ref>

== 制备 ==
萘普生铜通过[[萘普生钠]]与二价铜盐（如[[硫酸铜]]）的反应来制备。<ref name="Melnik">{{Cite journal |last1=Melnı́k |first1=Milan |last2=Macásková |first2=Lubov |last3=Holloway |first3=Clive E |last4=Mrozinski |first4=Jerzy |last5=Kalin’ska |first5=Bozena |date=March 2000 |title=Spectral and magnetic properties of copper(II) naproxenates |url=https://linkinghub.elsevier.com/retrieve/pii/S0020169399005046 |journal=Inorganica Chimica Acta |language=en |volume=299 |issue=2 |pages=284–287 |doi=10.1016/S0020-1693(99)00504-6 |access-date=2023-10-07 |archive-date=2018-06-22 |archive-url=https://web.archive.org/web/20180622080745/https://linkinghub.elsevier.com/retrieve/pii/S0020169399005046 |dead-url=no }}</ref>

<chem>2C14H13NaO3 + CuSO4 -> C28H26CuO6 + Na2SO4</chem>

== 参考资料 ==
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[[Category:二价铜化合物]]
[[Category:试验药物]]