查看“︁草酰羟乙酸还原酶 (脱羧)”︁的源代码

{{enzyme
| Name = 草酰羟乙酸还原酶 (脱羧)
| Systematic_name = D-glycerate:NAD(P)<sup>+</sup> oxidoreductase (carboxylating)
| Acronym = 
| Other_names = oxaloglycolate reductive decarboxylase
| EC_number = 1.1.1.92
| CAS_number = 37250-28-5
| IUBMB_EC_number = 1/1/1/92
| GO_code = 0047047
| image = 
| width = 
| caption = 
}}
'''草酰羟乙酸还原酶 (脱羧)'''（{{lang-en|oxaloglycolate reductase (decarboxylating)}}，[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.92 1.1.1.92] {{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.92 |date=20120813182900 }}），是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]：

:D-[[甘油酸]] + [[烟酰胺腺嘌呤二核苷酸|NAD]]([[烟酰胺腺嘌呤二核苷酸磷酸|P]])<sup>+</sup> + [[二氧化碳|CO<sub>2</sub>]]<math>\rightleftharpoons</math> 2-[[羟基]]-3-[[氧代琥珀酸]] + NAD(P)H + [[氢离子|H<sup>+</sup>]]

草酰羟乙酸还原酶 (脱羧)主要负责催化由[[二羟基延胡索酸]]（dihydroxyfumarate）和还原型[[三磷酸吡啶核苷酸]]（reduced triphosphopyridine nucleotide，TPNH）或还原型[[二磷酸吡啶核苷酸]]（reduced diphosphofyridine nucleotide，DPNH）到D-甘油酸的转化过程（但二羟基延胡索酸、草酰羟乙酸对应的[[酮]]被认为才是这种酶实际中作用的[[底物]]）。这种酶还能将[[羟基丙酮酸]]还原为D-甘油酸或将[[乙醛酸]]还原为[[乙醇酸]]。上述两个反应均需要还原型[[吡啶核苷酸]]。这种酶主要参与[[乙醛酸及二羧酸代谢]]（glyoxylate and dicarboxylate metabolism）。酰羟乙酸还原酶 (脱羧)的[[相对分子质量]]约为63,000[[原子质量单位|D]]。<ref>{{cite journal | author = Kohn LD, Jakoby WB | date = 1968 | title = Tartaric acid metabolism. VI. Crystalline oxaloglycolate reductive decarboxylase | journal = J. Biol. Chem.  | volume = 243 | pages = 2486-2493  | pmid = 4385076 | issue = 10 }}</ref>[[恶臭假单胞菌]]（''Pseudomonas putida''）参与[[酒石酸]][[代谢]]过程的草酰羟乙酸还原酶 (脱羧)具有A特异性，揭示出其可能是由同样具有A特异性的[[苹果酸脱氢酶]]演化而来的。<ref>{{cite journal | author = Do Nascimento, K.H.; Davies, D.D. | title = The stereospecificity of sequential nicotinamide-adenine dinucleotide-dependent oxidoreductases in relation to the evolution of metabolic sequences | journal = Biochem. J. | volume = 149 | issue = 3 | pages = 553-557 | pmid = 1200995 | PMC = 1165661 | url = http://www.ncbi.nlm.nih.gov/pubmed/1200995 | date = 1975-09 | access-date = 2014-03-24 | archive-date = 2014-03-24 | archive-url = https://web.archive.org/web/20140324190435/http://www.ncbi.nlm.nih.gov/pubmed/1200995 | dead-url = no }}</ref>

== 参考文献 ==
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{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NADH依赖性酶]]
[[Category:NADPH依赖性酶]]
[[Category:未知结构的酶]]