查看“︁苯丙氨酸氨裂合酶”︁的源代码

{{refimprove|time=2020-12-11T17:39:53+00:00}}
{{enzyme
| Name = 苯丙氨酸氨裂合酶
| EC_number = 4.3.1.5
| CAS_number = 9024-28-6
| IUBMB_EC_number = 4/3/1/5
| GO_code = 0045548
| image = 3nz4.jpg
| width = 270
| caption = 
}}
'''苯丙氨酸氨裂合酶'''（{{lang-en|phenylalanine ammonia-lyase}}，或称为'''苯丙氨酸解氨酶'''，简称为'''PAL'''，{{EC|4.3.1.24}}）是一种[[催化]]如下[[化学反应]]的[[酶]]：

:L-苯丙氨酸 <math>\rightleftharpoons</math> 反式-肉桂酸 + NH<sub>3</sub>

因此，这种反应有一种[[底物]]L-[[苯丙氨酸]]，以及两种[[产物 (化学)|产物]]反式-[[肉桂酸]]和[[氨]]。

这种酶属於[[裂合酶]]，而且是解氨酶，专门分解C-N键。此酶的系统命名为“L-phenylalanine ammonia-lyase (trans-cinnamate-forming)”。其他的英文俗名包括tyrase, phenylalanine deaminase、tyrosine ammonia-lyase、L-tyrosine ammonia-lyase、phenylalanine ammonium-lyase以及L-phenylalanine ammonia-lyase。这种酶会参与5个[[代谢途径]]：[[酪氨酸|酪氨酸代谢]]、[[苯丙氨酸|苯丙氨酸代谢]]、[[氮循环|氮代谢]]、[[苯丙素苷|苯丙素苷生物合成]]以及[[生物碱|生物碱生物合成ii]]。

==结构研究==

截至2007年底，这种酶的5种[[三級結構]]已经被分析出来，可通过以下几个[[蛋白質資料庫]]访问码查看：{{PDB link|1T6J}}、{{PDB link|1T6P}}、{{PDB link|1W27}}、{{PDB link|1Y2M}}、{{PDB link|2NYF}}。

==参考文献==
{{reflist|1}}
* {{cite journal | author = KOUKOL J, CONN EE | date = 1961 | title = The metabolism of aromatic compounds in higher plans. IV Purification and properties of the phenylalanine deaminase of Hordeum vulgare | url = https://archive.org/details/sim_journal-of-biological-chemistry_1961-10_236_10/page/2692 | journal = J. Biol. Chem.  | volume = 236 | pages = 2692–8  | pmid = 14458851 }}
* {{cite journal | author = Young MR and Neish AC | date = 1966 | title = Properties of the ammonia-lyases deaminating phenylalanine and related compounds in Triticum sestivum and Pteridium aquilinum | url = https://archive.org/details/sim_phytochemistry_1966_5/page/1121 | journal = [[Phytochemistry (journal)|Phytochemistry]]  | volume = 5 | pages = 1121–1132 | doi = 10.1016/S0031-9422(00)86105-1 }}

[[Category:EC 4.3.1]]
[[Category:已知结构的酶]]