查看“︁芳基醇脱氢酶 (NADP+)”︁的源代码

{{DISPLAYTITLE:芳基醇脱氢酶 (NADP<sup>+</sup>)}}
{{enzyme
| Name = 芳基醇脱氢酶 (NADP<sup>+</sup>)
| Systematic_name = aryl-alcohol:NADP<sup>+</sup> oxidoreductase
| Acronym = 
| Other_names = aryl alcohol dehydrogenase (nicotinamide adenine dinucleotide phosphate); coniferyl alcohol dehydrogenase; NADPH-linked benzaldehyde reductase; aryl-alcohol dehydrogenase (NADP)
| EC_number = 1.1.1.91
| CAS_number = 37250-27-4
| IUBMB_EC_number = 1/1/1/91
| GO_code = 0047681
| image = 
| width = 
| caption = 
}}
'''芳基醇脱氢酶 (NADP<sup>+</sup>)'''（{{lang-en|aryl-alcohol dehydrogenase (NADP<sup>+</sup>)}}，[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.91 1.1.1.91] {{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.91 |date=20190505114156 }}），是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]：

:[[芳基]][[醇]] + [[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]] <math>\rightleftharpoons</math> 芳基[[醛]] + NADPH + [[氢离子|H<sup>+</sup>]]

芳基醇脱氢酶 (NADP<sup>+</sup>)的[[等电点]]为5.2，在[[pH值]]为6.1时活性最高。这种酶主要作用在芳基醇上，但也能作用于一些芳基醛，但不能还原芳基[[酮]]。现发现最适合芳基醇脱氢酶 (NADP<sup>+</sup>)的[[底物]]是[[肉桂醛]]。这种酶对[[苯环]]上有[[甲基]][[取代基]]的底物比有[[羟基]]取代基的底物具有更强的特异性。<ref>{{cite journal | author = Andreas Muheim, Roland Waldner, Dominique Sanglard, Jakob Reiser, Hans E. Schoemaker, Matti S. A. Leisola | title = Purification and properties of an aryl-alcohol dehydrogenase from the white-rot fungus ''Phanerochaete chrysosporium'' | journal = European Journal of Biochemistry | volume = 195 | issue = 2 | pages = 369-375 | doi = 10.1111/j.1432-1033.1991.tb15715.x | url = http://onlinelibrary.wiley.com/doi/10.1111/j.1432-1033.1991.tb15715.x/full|date=Jan 1991}}</ref>芳基醇脱氢酶 (NADP<sup>+</sup>)能被[[对-氯汞基苯甲酸盐]]（''p''-chloromercuribenzoate，pCMB）或[[邻菲罗啉|1,10-菲罗啉]]抑制。<ref>{{cite journal | author = N.H. Sloane | title = Metablites of ''p''-aminobenzoic acid V. Isolation and properties of ''p''-aminobenzyl alcohol dehydrogenase | journal = Biochimica et Biophysica Acta (BBA)-Enzymology | volume = 327 | issue = 1 | pages = 11-18 | doi = 10.1016/0005-2744(73)90097-1 | url = http://www.sciencedirect.com/science/article/pii/0005274473900971 |date=Nov 15, 1973}}</ref>

== 参考文献 ==
{{reflist}}
{{refbegin}}
* {{cite journal | author = Gross GG, Zenk MH | date = 1969 | title = Reduction of aromatic acids to aldehydes and alcohols in the cell-free system. 2. Purification and properties of aryl-alcohol: NADP-oxidoreductase from ''Neurospora crassa'' | journal = Eur. J. Biochem.  | volume = 8 | pages = 420-425  | pmid = 4389864 | issue = 3 }}
{{refend}}

{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NADPH依赖性酶]]
[[Category:未知结构的酶]]