查看“︁肉碱3-脱氢酶”︁的源代码

{{enzyme
| Name = 肉碱3-脱氢酶
| Systematic_name = carnitine:NAD<sup>+</sup> oxidoreductase
| Acronym = CDH
| Other_names = L-carnitine dehydrogenase
| EC_number = 1.1.1.108
| CAS_number = 9045-45-8
| IUBMB_EC_number = 1/1/1/108
| GO_code = 0047728
| image = 
| width = 
| caption = 
}}
'''肉碱3-脱氢酶'''（{{lang-en|carnitine 3-dehydrogenase}}，[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.108 1.1.1.108] {{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.108 |date=20201116201115 }}），是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]：

:[[肉碱]] + [[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]] <math>\rightleftharpoons</math> 3-[[脱氢肉碱]] + NADH + [[氢离子|H<sup>+</sup>]]

上述反应是[[肉碱|L-肉碱]][[生物降解]]过程的第一步，<ref>{{cite journal | author = Hanschmann H, Ehricht R, Kleber HP. | title = Purification and properties of L(-)-carnitine dehydrogenase from ''Agrobacterium sp.'' | journal = Biochim Biophys Acta. | volume = 1290 | issue = 2 | pages = 177-183 | pmid = 8645721 | url = http://www.ncbi.nlm.nih.gov/pubmed/8645721 |date=Jun 4, 1996}}</ref>该反应被用于L-肉碱生产以及量化地鉴定[[生物]][[体液]]中L-肉碱的水平。<ref>{{cite journal | author = Clemens Uanschou, Roswitha Frieht, and Fritz Pittner | title = What to Learn from a Comparative Genomic Sequence Analysis of L-Carnitine Dehydrogenase | journal = Monatsh. Chem. | volume = 136 | issue = 8 | pages = 1365-1381 | year = 2005 | doi = 10.1007/s00706-005-0331-x | url = http://www.springerlink.com/content/kn5531797l238128/ }}{{Dead link|date=2020年3月 |bot=InternetArchiveBot |fix-attempted=yes }}</ref>从[[根瘤菌]]（''Rhizobium sp.''）和[[半透明黄单胞菌]]（''Xanthomonas translucens''）[[细胞]]中分别提取出的肉碱3-脱氢酶Rs-CDH和Xt-CDH的[[相对分子质量]]分别为50[[原子质量单位|kDa]]和37kDa，它们的[[蛋白质一级结构|初级结构]]与[[3-羟酰辅酶A脱氢酶]]有高度的相似性。<ref>{{cite journal | author = Arima J, Uesumi A, Mitsuzumi H, Mori N. | title = Biochemical characterization of L-carnitine dehydrogenases from ''izobium sp.'' and ''Xanthomonas translucens''. | journal = Biosci Biotechnol Biochem. | year = 2010 | volume = 74 | issue = 6 | pages = 1237-1242 | pmid = 20530902 | url = http://www.ncbi.nlm.nih.gov/pubmed/20530902 }}</ref>

== 参考文献 ==
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{{refbegin}}
* {{cite journal | author = Aurich H, Kleber HP, Sorger H, Tauchert H | date = 1968 | title = Purification and properties of carnitine dehydrogenase from ''Pseudomonas aeruginosa'' | journal = Eur. J. Biochem.  | volume = 6 | pages = 196–201  | pmid = 4302217 | doi = 10.1111/j.1432-1033.1968.tb00437.x | issue = 2 }}
* {{cite journal | author = Schopp W, Sorger H, Kleber HP, Aurich H | date = 1969 | title = Kinetic studies of the reaction mechanism of carnitine dehydrogenase of ''Pseudomonas aeruginosa'' | journal = Eur. J. Biochem.  | volume = 10 | pages = 56–60  | pmid = 4310279 | issue = 1 | doi=10.1111/j.1432-1033.1969.tb00654.x }}
{{refend}}

{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NADH依赖性酶]]
[[Category:未知结构的酶]]