查看“︁羟甲基戊二酸单酰辅酶A还原酶 (NADPH)”︁的源代码

{{about|[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]的酶|同名但以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]为受体的酶|羟甲基戊二酸单酰辅酶A还原酶}}
{{enzyme
| Name = 羟甲基戊二酸单酰辅酶A还原酶 (NADPH)
| Systematic_name = (''R'')-mevalonate:NADP<sup>+</sup> oxidoreductase (CoA-acylating)
| Acronym = 
| Other_names = hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate); 3-hydroxy-3-methylglutaryl-CoA reductase; β-hydroxy-β-methylglutaryl coenzyme A reductase; hydroxymethylglutaryl CoA reductase (NADPH); ''S''-3-hydroxy-3-methylglutaryl-CoA reductase; NADPH-hydroxymethylglutaryl-CoA reductase; HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA); 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); hydroxymethylglutaryl-CoA reductase (NADPH<sub>2</sub>)
| EC_number = 1.1.1.34
| CAS_number = 9028-35-7 
| IUBMB_EC_number = 1/1/1/34 
| GO_code = 0004420 
| image = Protein HMGCR PDB 1dq8.png
| width = 
| caption = 羟甲基戊二酸单酰辅酶A还原酶晶体结构（[[蛋白质数据库|PDB]] 1dq8）<ref>{{cite journal | author = Istvan, E.S.,  Palnitkar, M.,  Buchanan, S.K.,  Deisenhofer, J. | title = Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis | journal = EMBO J. | year = 2000 | volume = 19 | pages = 819-830 | pmid = 10698924 | id = PMCID PMC305622 | doi = 10.1093/emboj/19.5.819 | url = http://www.ncbi.nlm.nih.gov/pubmed/10698924?dopt=Abstract | access-date = 2012-06-03 | archive-date = 2014-04-07 | archive-url = https://web.archive.org/web/20140407090234/http://www.ncbi.nlm.nih.gov/pubmed/10698924?dopt=Abstract | dead-url = no }}</ref>
}}
'''羟甲基戊二酸单酰辅酶A还原酶 (NADPH)'''（{{lang-en|hydroxymethylglutaryl-CoA reductase (NADPH)}}，[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.34 1.1.1.34] {{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.34 |date=20120518005145 }}）是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]：

:(''R'')-[[甲羟戊酸]] + [[辅酶A|CoA]] + 2 [[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]] <math>\rightleftharpoons</math> (''S'')-[[3-羟基-3-甲基戊二酰辅酶A]] + 2 NADPH + 2 [[氢离子|H<sup>+</sup>]]

羟甲基戊二酸单酰辅酶A还原酶 (NADPH)主要参与诸如[[胆固醇]]等[[类固醇]]的合成。用于降低胆固醇的[[他汀类药物]]通过[[酶抑制剂|抑制]]这种酶来发挥作用。

== 参考文献 ==
{{reflist}}
{{refbegin}}
* {{cite journal | author = Bucher NLR, Overath P and Lynen F | date = 1960 | title = beta-Hydroxy-beta-methylglutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver | url = https://archive.org/details/sim_biochimica-et-biophysica-acta-international-jo_biochimica-et-biophysica-acta_1960_40/page/n501 | journal = Biochim. Biophys. Acta  | volume = 40 | pages = 491–501 | doi = 10.1016/0006-3002(60)91390-1 | pmid=13805544}}
* {{cite journal | author = DURR IF, RUDNEY H | date = 1960 | title = The reduction of beta-hydroxy-beta-methyl-glutaryl coenzyme A to mevalonic acid | url = https://archive.org/details/sim_journal-of-biological-chemistry_1960-09_235_9/page/2572 | journal = J. Biol. Chem.  | volume = 235 | pages = 2572–8  | pmid = 13818862 }}
* {{cite journal | author = Kawachi T, Rudney H | date = 1970 | title = Solubilization and purification of beta-hydroxy-beta-methylglutaryl coenzyme A reductase from rat liver | journal = Biochemistry.  | volume = 9 | pages = 1700–5  | pmid = 4985697 | doi = 10.1021/bi00810a008 | issue = 8 }}
{{refend}}

{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NADPH依赖性酶]]
[[Category:已知结构的酶]]