查看“︁磷酸甘油酸脱氢酶”︁的源代码

{{enzyme
| Name = 磷酸甘油酸脱氢酶
| Systematic_name = 3-phospho-D-glycerate:NAD<sup>+</sup> 2-oxidoreductase
| Acronym = PHGDH
| Other_names = D-3-phosphoglycerate:NAD<sup>+</sup> oxidoreductase; α-phosphoglycerate dehydrogenase; 3-phosphoglycerate dehydrogenase; 3-phosphoglyceric acid dehydrogenase; D-3-phosphoglycerate dehydrogenase; glycerate 3-phosphate dehydrogenase; glycerate-1,3-phosphate dehydrogenase; phosphoglycerate oxidoreductase; phosphoglyceric acid dehydrogenase; SerA; 3-phosphoglycerate:NAD<sup>+</sup> 2-oxidoreductase; SerA 3PG dehydrogenase; 3PHP reductase; αKG reductase; D- and L-HGA
| EC_number = 1.1.1.95
| CAS_number = 9075-29-0
| IUBMB_EC_number = 1/1/1/95
| GO_code = 0004617
| image = PDB 2g76 EBI.png
| width = 
| caption = 
}}
{{PBB|geneid=26227}}
'''磷酸甘油酸脱氢酶'''（{{lang-en|phosphoglycerate dehydrogenase}}，[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.95 1.1.1.95] {{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.95 |date=20121006200350 }}），是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下两种[[酶促反应]]：

:[[3-磷酸甘油酸|3-磷酸化-D-甘油酸]] + [[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]] <math>\rightleftharpoons</math> 3-磷酸羟基丙酮酸 + NADH + [[氢离子|H<sup>+</sup>]]
:2-羟基戊二酸 + NAD<sup>+</sup> <math>\rightleftharpoons</math> [[α-酮戊二酸]] + NADH + H<sup>+</sup>

在[[大肠杆菌]]（''Escherichia coli''）中，磷酸甘油酸脱氢酶参与催化[[丝氨酸]][[生物合成]]的[[磷酸丝氨酸途径]]中的第一步，<ref>{{cite journal | author = Pizer, L.I. | title =The mechanism of end product inhibition of serine biosynthesis. I. Purification and kinetics of phosphoglycerate dehydrogenase | journal = J. Biol. Chem. | volume = 243 | year = 1986 | pages = 2081-2089 | pmid = 4384871 }}</ref>上述[[可逆反应]]主要逆向进行。磷酸甘油酸脱氢酶可被丝氨酸或[[甘氨酸]]抑制。这种酶很不寻常，因为它还能像D-2-羟基戊二酸脱氢酶和L-2-羟基戊二酸脱氢酶一样还原[[α-酮戊二酸]]，其中，D型[[底物]]更适合磷酸甘油酸脱氢酶。<ref>{{Cite journal|author=Zhao, G. and Winkler, M.E.|title=A novel &alpha;-ketoglutarate reductase activity of the ''serA''-encoded 3-phosphoglycerate dehydrogenase of ''Escherichia coli'' K-12 and its possible  implications for human 2-hydroxyglutaric aciduria|url=https://archive.org/details/sim_journal-of-bacteriology_1996-01_178_1/page/232|journal=J. Bacteriol.|volume=178|year=1996|pages=232–239|pmid=8550422}}</ref>

== 参考文献 ==
{{reflist}}
{{refbegin}}
* {{Cite journal|author=Sugimoto, E. and Pizer, L.I.|title=The mechanism of end product inhibition of serine biosynthesis. I. Purification and kinetics of phosphoglycerate dehydrogenase|journal=J. Biol. Chem.|volume=243|year=1968|pages=2081–1089|pmid=4384871}}
* {{Cite journal|author=Schuller, D.J., Grant, G.A. and Banaszak, L.J.|title=The allosteric ligand site in the V<small><sub>max</sub></small>-type cooperative enzyme phosphoglycerate dehydrogenase|journal=Nat. Struct. Biol.|volume=2|year=1995|pages=69–76|pmid=7719856}}
{{refend}}

== 扩展阅读 ==
{{refbegin}}
* {{cite journal  | author=Tsang HT, Connell JW, Brown SE, ''et al.'' |title=A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. |journal=Genomics |volume=88 |issue= 3 |pages= 333–346 |year= 2006 |pmid= 16730941 |doi= 10.1016/j.ygeno.2006.04.003 }}
* {{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–321 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
* {{cite journal  | author=Guo D, Han J, Adam BL, ''et al.'' |title=Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. |journal=Biochem. Biophys. Res. Commun. |volume=337 |issue= 4 |pages= 1308–18 |year= 2005 |pmid= 16236267 |doi= 10.1016/j.bbrc.2005.09.191 }}
* {{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
* {{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
* {{cite journal  | author=Pind S, Slominski E, Mauthe J, ''et al.'' |title=V490M, a common mutation in 3-phosphoglycerate dehydrogenase deficiency, causes enzyme deficiency by decreasing the yield of mature enzyme. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7136–7143 |year= 2002 |pmid= 11751922 |doi= 10.1074/jbc.M111419200 }}
* {{cite journal  | author=Klomp LW, de Koning TJ, Malingré HE, ''et al.'' |title=Molecular characterization of 3-phosphoglycerate dehydrogenase deficiency--a neurometabolic disorder associated with reduced L-serine biosynthesis. |journal=Am. J. Hum. Genet. |volume=67 |issue= 6 |pages= 1389–1399 |year= 2001 |pmid= 11055895 |doi=10.1086/316886  | pmc=1287916  }}
* {{cite journal  | author=Pineda M, Vilaseca MA, Artuch R, ''et al.'' |title=3-phosphoglycerate dehydrogenase deficiency in a patient with West syndrome. | url=https://archive.org/details/sim_developmental-medicine-and-child-neurology_2000-09_42_9/page/629 |journal=Developmental medicine and child neurology |volume=42 |issue= 9 |pages= 629–633 |year= 2000 |pmid= 11034457 |doi=10.1017/S0012162200001171  }}
* {{cite journal  | author=Baek JY, Jun DY, Taub D, Kim YH |title=Assignment of human 3-phosphoglycerate dehydrogenase (PHGDH) to human chromosome band 1p12 by fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=89 |issue= 1-2 |pages= 6–7 |year= 2000 |pmid= 10894924 |doi=10.1159/000015577  }}
* {{cite journal  | author=Cho HM, Jun DY, Bae MA, ''et al.'' |title=Nucleotide sequence and differential expression of the human 3-phosphoglycerate dehydrogenase gene. |journal=Gene |volume=245 |issue= 1 |pages= 193–201 |year= 2000 |pmid= 10713460 |doi=10.1016/S0378-1119(00)00009-3  }}
* {{cite journal  | author=Jaeken J, Detheux M, Van Maldergem L, ''et al.'' |title=3-Phosphoglycerate dehydrogenase deficiency: an inborn error of serine biosynthesis. | url=https://archive.org/details/sim_archives-of-disease-in-childhood_1996-06_74_6/page/542 |journal=Arch. Dis. Child. |volume=74 |issue= 6 |pages= 542–545 |year= 1996 |pmid= 8758134 |doi=10.1136/adc.74.6.542  | pmc=1511571  }}
{{refend}}
{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NADH依赖性酶]]
[[Category:已知结构的酶]]