查看“︁泛解酸4-脱氢酶”︁的源代码

{{enzyme
| Name = 泛解酸4-脱氢酶
| Systematic_name = (''R'')-pantoate:NAD<sup>+</sup> oxidoreductase
| Acronym = 
| Other_names = pantoate dehydrogenase; pantothenase; D-pantoate:NAD<sup>+</sup> 4-oxidoreductase
| EC_number = 1.1.1.106
| CAS_number = 37250-38-7
| IUBMB_EC_number = 1/1/1/106
| GO_code = 0050166
| image = 
| width = 
| caption = 
}}
'''泛解酸4-脱氢酶'''（{{lang-en|pantoate 4-dehydrogenase}}，[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.106 1.1.1.106] {{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.106 |date=20200812213819 }}）也称为“'''泛解酸脱氢酶'''”，是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]：

:(''R'')-[[泛解酸]] + [[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]] <math>\rightleftharpoons</math> (''R'')-4-[[脱氢泛解酸]] + NADH + [[氢离子|H<sup>+</sup>]]

从[[荧光假单胞菌]]（''Pseudomonas fluorescens''）[[细胞]]中提取出的泛解酸4-脱氢酶的[[相对分子质量]]约为83,000[[原子质量单位|D]]，可以分离产生4个相对分子质量约为24,000D的[[蛋白质亚基]]。<ref>{{cite journal | author = Mäntsälä P. | title = Purification of pantoate and dimethylmalate dehydrogenase from ''Pseudomonas fluorescens'' UK-1. | journal = Biochim Biophys Acta. | date = 1978-09-11| volume = 526 | issue = 1 | pages = 25-33 | pmid = 99175 | url = http://www.ncbi.nlm.nih.gov/pubmed/99175 }}</ref>这种酶对[[对-氯汞基苯甲酸盐]]、5,5'-二硫代双(2-硝基苯甲酸)、[[碘乙酸]]和[[苯基乙二醛]]的去活化作用敏感，而[[泛解酸]]和NAD能对抗上述[[酶抑制剂]]中前三种的去活化作用，它们对苯基乙二醛去活化作用下的泛解酸4-脱氢酶也有持续的保护作用。<ref>{{cite journal | author = Myöhänen T, Mäntsälä P. | title = Evidence for the importance of cysteine and arginine residues in ''Pseudomonas fluorescens'' UK-1 pantoate dehydrogenase. | journal = Biochim Biophys Acta. | volume = 614 | issue = 2 | pages = 266-273 | pmid = 6773579 | url = http://www.ncbi.nlm.nih.gov/pubmed/6773579 |date=Aug 7, 1980}}</ref>泛解酸4-脱氢酶主要参与[[泛酸]]及[[辅酶A]]的[[生物合成]]过程。

== 参考文献 ==
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* {{cite journal | author = Goodhue CT, Snell EE | date = 1966 | title = The bacterial degradation of pantothenic acid. 3. Enzymatic formation of aldopantoic acid | journal = Biochemistry. | volume = 5 | issue = 2 | year = 1966 | pages = 403-408 | pmid = 4287370 | doi = 10.1021/bi00866a003 | url = http://www.ncbi.nlm.nih.gov/pubmed/4287370 | access-date = 2012-08-16 | archive-date = 2016-05-27 | archive-url = https://web.archive.org/web/20160527225320/http://www.ncbi.nlm.nih.gov/pubmed/4287370 | dead-url = no }}
{{refend}}

{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NADH依赖性酶]]
[[Category:未知结构的酶]]