查看“︁全反式视黄醇脱氢酶 (NAD+)”︁的源代码

{{DISPLAYTITLE:全反式视黄醇脱氢酶 (NAD<sup>+</sup>)}}
{{enzyme
| Name = 全反式视黄醇脱氢酶 (NAD<sup>+</sup>)
| Systematic_name = ''all-trans'' retinol:NAD<sup>+</sup> oxidoreductase
| Acronym = MDR
| Other_names = retinol (vitamin A<sub>1</sub>) dehydrogenase; microsomal retinol dehydrogenase; retinol dehydrogenase (misleading); retinal reductase; retinene reductase; epidermal retinol dehydrogenase 2
| EC_number = 1.1.1.105
| CAS_number = 9033-53-8
| IUBMB_EC_number = 1/1/1/105
| GO_code = 0004745
| image = 
| width = 
| caption = 
}}
'''全反式视黄醇脱氢酶 (NAD<sup>+</sup>)'''（{{lang-en|''all-trans''-retinol dehydrogenase (NAD<sup>+</sup>)}}，[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.105 1.1.1.105] {{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.105 |date=20201127225456 }}），是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]：

:全反式[[视黄醇]]-[[视黄醇结合蛋白]] + [[烟酰胺腺嘌呤二核苷酸|NAD]]<sup>+</sup> <math>\rightleftharpoons</math> 全反式[[视黄醛]]-视黄醇结合蛋白 + NADH + [[氢离子|H<sup>+</sup>]]

全反式视黄醇脱氢酶 (NAD<sup>+</sup>)能以全反式[[视黄醇]]和全反式[[视黄醛]]为[[底物]]，且对NAD<sup>+</sup>/NADH[[辅因子]]有很强的特异性。这种酶既能识别处于[[游离态]]的底物也能识别与[[视黄醇结合蛋白]]相结合时的底物，但对结合状态下的底物具有更高的亲和性。<ref>{{cite journal | author = Gough, W.H., VanOoteghem, S., Sint, T. and Kedishvili, N.Y. | title = cDNA cloning and characterization of a new human microsomal NAD<sup>+</sup>-dependent dehydrogenase that oxidizes ''all-trans''-retinol and 3α-hydroxysteroids. | journal =  J. Biol. Chem. | volume = 273 | year = 1998 | pages = 19778-19785 | pmid = 9677409 }}</ref>


== 参考文献 ==
{{reflist}}
{{refbegin}}
* {{cite journal | author = Koen AL, Shaw CR | date = 1966 | title = Retinol and alcohol dehydrogenases in retina and liver | journal = Biochim. Biophys. Acta.  | volume = 128 | pages = 48–54  | pmid = 5972368 }}
* {{cite journal | author = Matsuzaka, Y., Okamoto, K., Tsuji, H., Mabuchi, T., Ozawa, A., Tamiya, G. and Inoko, H. | title = Identification of the hRDH-E2 gene, a novel member of the SDR family, and its increased expression in psoriatic lesion. | journal = Biochem. Biophys. Res. Commun. | volume = 297 | year = 2002 | pages = 1171-1180 | pmid = 12372410}}
* {{cite journal | author = Lee, S.A., Belyaeva, O.V. and Kedishvili, N.Y. | title = Biochemical characterization of human epidermal retinol dehydrogenase 2. | journal = Chem. Biol. Interact. | volume = 178 | year = 2009 | pages = 182-187 | pmid = 18926804}}
{{refend}}

{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NADH依赖性酶]]
[[Category:未知结构的酶]]