查看“︁二甲基苹果酸脱氢酶”︁的源代码

{{enzyme
| Name = 二甲基苹果酸脱氢酶
| Systematic_name = (''R'')-3,3-dimethylmalate:NAD<sup>+</sup> oxidoreductase (decarboxylating)
| Acronym = 
| Other_names = β,β-dimethylmalate dehydrogenase
| EC_number = 1.1.1.84
| CAS_number = 37250-21-8 | IUBMB_EC_number = 1/1/1/84 | GO_code = 0047867 | image =
| width = 
| caption = 
}}
'''二甲基苹果酸脱氢酶'''（{{lang-en|dimethylmalate dehydrogenase}}，[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.84 1.1.1.84] {{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.84 |date=20200809153027 }}）是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]：

:(''R'')-3,3-[[二甲基苹果酸]] + [[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]] <math>\rightleftharpoons</math> 3-[[甲基]]-2-[[氧代丁酸]] + [[二氧化碳|CO<sub>2</sub>]] + NADH

主要参与[[泛酸]]与[[辅酶A]]的合成过程，还能作用于(''R'')-[[苹果酸]]。这种酶拥有5种[[辅酶]]，分别为：[[氨|NH<sub>3</sub>]]、[[二价锰离子|Mn<sup>2+</sup>]]、[[二价钴离子|Co<sup>2+</sup>]]、[[钾|K<sup>+</sup>]]和[[铵离子|NH<sub>4</sub><sup>+</sup>]]，作用时K<sup>+</sup>与NH<sub>4</sub><sup>+</sup>、Mn<sup>2+</sup>与Co<sup>2+</sup>可相互替代。

== 参考文献 ==
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* {{cite journal | author = Magee PT, Snell EE | date = 1966 | title = The bacterial degradation of pantothenic acid. IV. Enzymatic conversion of aldopantoate to alpha-ketoisovalerate | journal = Biochemistry.  | volume = 5 | pages = 409–16  | pmid = 4287371 | doi = 10.1021/bi00866a004 | issue = 2 }}
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{{EC 1.1}}

[[Category:EC 1.1.1]]
[[Category:NADH依赖性酶]]
[[Category:未知结构的酶]]
[[Category:锰酶]]
[[Category:钴酶]]
[[Category:钾酶]]
[[Category:铵酶]]